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10.1016/j.febslet.2014.03.009 http://scihub22266oqcxt.onion/10.1016/j.febslet.2014.03.009 C4060616!4060616!24642372     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+Lett 2014 ; 588 (8): 1416-22 Nephropedia Template TP {{tp|p=24642372|t=2014. The Role of Pannexin1 in the Induction and Resolution of Inflammation |pdf=|usr=}}{{24642372}} gab.com Text The Role of Pannexin1 in the Induction and Resolution of Inflammation JO: FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=24642372 #FOAvip Extracellular ATP is an important signaling molecule throughout the inflammatory cascade, serving as a danger signal that causes activation of the inflammasome, enhancement of immune cell infiltration, and fine-tuning of several signaling cascades including those important for the resolution of inflammation. Recent studies demonstrated that ATP can be released from cells in a controlled manner through pannexin (Panx) channels. Panx1-mediated ATP release is involved in inflammasome activation and neutrophil/macrophage chemotaxis, activation of T cells, and a role for Panx1 in inducing and propagating inflammation has been demonstrated in various organs, including lung and the central and peripheral nervous system. The recognition and clearance of dying cells and debris from focal points of inflammation is critical in the resolution of inflammation, and Panx1-mediated ATP release from dying cells has been shown to recruit phagocytes. Moreover, extracellular ATP can be broken down by ectonucleotidases into ADP, AMP, and adenosine, which is critical in the resolution of inflammation. Together, Panx1, ATP, purinergic receptors, and ectonucleotidases contribute to important feedback loops during the inflammatory response, and thus represent promising candidates for new therapies. Twit Text FOAVip The Role of Pannexin1 in the Induction and Resolution of Inflammation ????FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=24642372 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24642372 #FOAvip English Wikipedia <ref>{{Cite pmid|24642372}}</ref> The Role of Pannexin1 in the Induction and Resolution of Inflammation #MMPMID24642372 Adamson SE; Leitinger N FEBS Lett 2014[Apr]; 588 (8): 1416-22 PMID24642372show ga Extracellular ATP is an important signaling molecule throughout the inflammatory cascade, serving as a danger signal that causes activation of the inflammasome, enhancement of immune cell infiltration, and fine-tuning of several signaling cascades including those important for the resolution of inflammation. Recent studies demonstrated that ATP can be released from cells in a controlled manner through pannexin (Panx) channels. Panx1-mediated ATP release is involved in inflammasome activation and neutrophil/macrophage chemotaxis, activation of T cells, and a role for Panx1 in inducing and propagating inflammation has been demonstrated in various organs, including lung and the central and peripheral nervous system. The recognition and clearance of dying cells and debris from focal points of inflammation is critical in the resolution of inflammation, and Panx1-mediated ATP release from dying cells has been shown to recruit phagocytes. Moreover, extracellular ATP can be broken down by ectonucleotidases into ADP, AMP, and adenosine, which is critical in the resolution of inflammation. Together, Panx1, ATP, purinergic receptors, and ectonucleotidases contribute to important feedback loops during the inflammatory response, and thus represent promising candidates for new therapies. äThe Role of Pannexin1 in the Induction and Resolution of Inflammation (epmc).pdf DeepDyve Pubget Overpricing