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10.1186/ar4230 http://scihub22266oqcxt.onion/10.1186/ar4230 C4060542!4060542!23796020     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arthritis+Res+Ther 2013 ; 15 (3): 215 Nephropedia Template TP {{tp|p=23796020|t=2013. Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells |pdf=|usr=}}{{23796020}} gab.com Text Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells JO: Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=23796020 #FOAvip Scleroderma (systemic sclerosis; SSc) is characterised by fibrosis of the skin and internal organs in the context of autoimmunity and vascular perturbation. Overproduction of extracellular matrix components and loss of specialised epithelial structures are analogous to the process of scar formation after tissue injury. Fibroblasts are the resident cells of connective tissue that become activated at sites of damage and are likely to be important effector cells in SSc. Differentiation into myofibroblasts is a hallmark process, although the mechanisms and cellular origins of this important fibroblastic cell are still unclear. This article reviews fibroblast biology in the context of SSc and highlights the potentially important place of fibroblast effector cells in fibrosis. Moreover, the heterogeneity of fibroblast properties, multiplicity of regulatory pathways and diversity of origin for myofibroblasts may underpin clinical diversity in SSc, and provide novel avenues for targeted therapy. Twit Text FOAVip Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells ????Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=23796020 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23796020 #FOAvip English Wikipedia <ref>{{Cite pmid|23796020}}</ref> Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells #MMPMID23796020 Gilbane AJ; Denton CP; Holmes AM Arthritis Res Ther 2013[]; 15 (3): 215 PMID23796020show ga Scleroderma (systemic sclerosis; SSc) is characterised by fibrosis of the skin and internal organs in the context of autoimmunity and vascular perturbation. Overproduction of extracellular matrix components and loss of specialised epithelial structures are analogous to the process of scar formation after tissue injury. Fibroblasts are the resident cells of connective tissue that become activated at sites of damage and are likely to be important effector cells in SSc. Differentiation into myofibroblasts is a hallmark process, although the mechanisms and cellular origins of this important fibroblastic cell are still unclear. This article reviews fibroblast biology in the context of SSc and highlights the potentially important place of fibroblast effector cells in fibrosis. Moreover, the heterogeneity of fibroblast properties, multiplicity of regulatory pathways and diversity of origin for myofibroblasts may underpin clinical diversity in SSc, and provide novel avenues for targeted therapy. äScleroderma pathogenesis: a pivotal role for fibroblasts as effector c(epmc).pdf DeepDyve Pubget Overpricing