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10.1186/ar3835 http://scihub22266oqcxt.onion/10.1186/ar3835 C4060361!4060361 !22571761     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22571761 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Arthritis+Res+Ther 2012 ; 14 (3 ): R110 Nephropedia Template TP {{tp|p=22571761 |t=2012. Mycophenolic acid counteracts B cell proliferation and plasmablast formation in patients with systemic lupus erythematosus |pdf=|usr=}}{{22571761 }} gab.com Text Mycophenolic acid counteracts B cell proliferation and plasmablast formation in patients with systemic lupus erythematosus JO: Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=22571761 #FOAvip INTRODUCTION: Clinical trials revealed a high efficacy of mycophenolate mofetil (MMF)in inducing and maintaining remission in patients with class III-V-lupus nephritis. Also extrarenal manifestations respond to MMF treatment. However, few attempts have been undertaken to delineate its mechanism of action in systemic lupus erythematosus (SLE) a disease characterized by enhanced B cell activation. METHODS: Clinical and paraclinical parameters of 107 patients with SLE were recorded consecutively and analyzed retrospectively. Patients were divided into treatment groups (MMF: n=39, azathioprine (AZA) n=30 and controls without immunosuppressive therapy n=38). To further delineate the effect of mycophenolic acid (MPA) on naive and memory B cells in vitro assays were performed. RESULTS: Although patients taking AZA flared more frequently than patients on MMF or controls, the analysis of clinical parameters did not reveal significant differences.However, profound differences in paraclinical parameters were found. B cell frequencies and numbers were significantly higher in patients taking MMF compared to those on AZA but lower numbers and frequencies of plasmablasts were detected compared to AZA-treated patients or controls. Notably, MMF treatment was associated with a significantly higher frequency and number of transitional B cells as well as naive B cells compared to AZA treatment. Differences in T cell subsets were not significant. MPA abrogated in vitro proliferation of purified B cells completely but had only moderate impact on B cell survival. CONCLUSIONS: The thorough inhibition of B cell activation and plasma cell formation by MMF might explain the favorable outcomes of previous clinical trials in patients with SLE, since enhanced B cell proliferation is a hallmark of this disease. Twit Text FOAVip Mycophenolic acid counteracts B cell proliferation and plasmablast formation in patients with systemic lupus erythematosus ????Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=22571761 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22571761 #FOAvip English Wikipedia <ref>{{Cite pmid|22571761 }}</ref> Mycophenolic acid counteracts B cell proliferation and plasmablast formation in patients with systemic lupus erythematosus #MMPMID22571761 Eickenberg S ; Mickholz E ; Jung E ; Nofer JR ; Pavenstadt HJ ; Jacobi AM Arthritis Res Ther 2012[]; 14 (3 ): R110 PMID22571761 show ga INTRODUCTION: Clinical trials revealed a high efficacy of mycophenolate mofetil (MMF)in inducing and maintaining remission in patients with class III-V-lupus nephritis. Also extrarenal manifestations respond to MMF treatment. However, few attempts have been undertaken to delineate its mechanism of action in systemic lupus erythematosus (SLE) a disease characterized by enhanced B cell activation. METHODS: Clinical and paraclinical parameters of 107 patients with SLE were recorded consecutively and analyzed retrospectively. Patients were divided into treatment groups (MMF: n=39, azathioprine (AZA) n=30 and controls without immunosuppressive therapy n=38). To further delineate the effect of mycophenolic acid (MPA) on naive and memory B cells in vitro assays were performed. RESULTS: Although patients taking AZA flared more frequently than patients on MMF or controls, the analysis of clinical parameters did not reveal significant differences.However, profound differences in paraclinical parameters were found. B cell frequencies and numbers were significantly higher in patients taking MMF compared to those on AZA but lower numbers and frequencies of plasmablasts were detected compared to AZA-treated patients or controls. Notably, MMF treatment was associated with a significantly higher frequency and number of transitional B cells as well as naive B cells compared to AZA treatment. Differences in T cell subsets were not significant. MPA abrogated in vitro proliferation of purified B cells completely but had only moderate impact on B cell survival. CONCLUSIONS: The thorough inhibition of B cell activation and plasma cell formation by MMF might explain the favorable outcomes of previous clinical trials in patients with SLE, since enhanced B cell proliferation is a hallmark of this disease. |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Azathioprine/therapeutic use [MESH] |B-Lymphocytes/cytology/*drug effects [MESH] |Cell Proliferation/*drug effects [MESH] |Female [MESH] |Flow Cytometry [MESH] |Humans [MESH] |Immunosuppressive Agents/*therapeutic use [MESH] |Lupus Erythematosus, Systemic/*drug therapy/immunology [MESH] |Lymphocyte Activation/*drug effects [MESH] |Male [MESH] |Middle Aged [MESH] |Mycophenolic Acid/*therapeutic use [MESH] |Plasma Cells/drug effects [MESH] |Retrospective Studies [MESH]Mycophenolic acid counteracts B cell proliferation and plasmablast for(epmc).pdf DeepDyve Pubget Overpricing