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10.1210/en.2014-1173 http://scihub22266oqcxt.onion/10.1210/en.2014-1173 C4060191!4060191!24758302     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Endocrinology 2014 ; 155 (7): 2363-76 Nephropedia Template TP {{tp|p=24758302|t=2014. Emerging Multifunctional Roles of Claudin Tight Junction Proteins in Bone |pdf=|usr=}}{{24758302}} gab.com Text Emerging Multifunctional Roles of Claudin Tight Junction Proteins in Bone JO: Endocrinology http://www.kidney.de/pget.php?&tw=1&pmid=24758302 #FOAvip The imbalance between bone formation and resorption during bone remodeling has been documented to be a major factor in the pathogenesis of osteoporosis. Recent evidence suggests a significant role for the tight junction proteins, Claudins (Cldns), in the regulation of bone remodeling processes. In terms of function, whereas Cldns act ?canonically? as key determinants of paracellular permeability, there is considerable recent evidence to suggest that Cldns also participate in cell signaling, ie, a ?noncanonical function?. To this end, Cldns have been shown to regulate cell proliferation, differentiation, and gene expression in a variety of cell types. The present review will discuss Cldns' structure, their expression profile, regulation of expression, and their canonical and non- canonical functions in general with special emphasis on bone cells. In order to shed light on the noncanonical functions of Cldns in bone, we will highlight the role of Cldn-18 in regulating bone resorption and osteoclast differentiation. Collectively, we hope to provide a framework for guiding future research on understanding how Cldns modulate osteoblast and osteoclast function and overall bone homeostasis. Such studies should provide valuable insights into the pathogenesis of osteoporosis, and may highlight Cldns as novel targets for the diagnosis and therapeutic management of osteoporosis. Twit Text FOAVip Emerging Multifunctional Roles of Claudin Tight Junction Proteins in Bone ????Endocrinology http://www.kidney.de/pget.php?&tw=1&pmid=24758302 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24758302 #FOAvip English Wikipedia <ref>{{Cite pmid|24758302}}</ref> Emerging Multifunctional Roles of Claudin Tight Junction Proteins in Bone #MMPMID24758302 Alshbool FZ; Mohan S Endocrinology 2014[Jul]; 155 (7): 2363-76 PMID24758302show ga The imbalance between bone formation and resorption during bone remodeling has been documented to be a major factor in the pathogenesis of osteoporosis. Recent evidence suggests a significant role for the tight junction proteins, Claudins (Cldns), in the regulation of bone remodeling processes. In terms of function, whereas Cldns act ?canonically? as key determinants of paracellular permeability, there is considerable recent evidence to suggest that Cldns also participate in cell signaling, ie, a ?noncanonical function?. To this end, Cldns have been shown to regulate cell proliferation, differentiation, and gene expression in a variety of cell types. The present review will discuss Cldns' structure, their expression profile, regulation of expression, and their canonical and non- canonical functions in general with special emphasis on bone cells. In order to shed light on the noncanonical functions of Cldns in bone, we will highlight the role of Cldn-18 in regulating bone resorption and osteoclast differentiation. Collectively, we hope to provide a framework for guiding future research on understanding how Cldns modulate osteoblast and osteoclast function and overall bone homeostasis. Such studies should provide valuable insights into the pathogenesis of osteoporosis, and may highlight Cldns as novel targets for the diagnosis and therapeutic management of osteoporosis. äEmerging Multifunctional Roles of Claudin Tight Junction Proteins in B(epmc).pdf DeepDyve Pubget Overpricing