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2014 ; 24
(3
): 210-7
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Magnetic resonance imaging of the tumor microenvironment in radiotherapy:
perfusion, hypoxia, and metabolism
#MMPMID24931096
Matsuo M
; Matsumoto S
; Mitchell JB
; Krishna MC
; Camphausen K
Semin Radiat Oncol
2014[Jul]; 24
(3
): 210-7
PMID24931096
show ga
The tumor microenvironment is characterized by hypoxia, low pH, and high
interstitial fluid pressure. Hypoxic regions in tumors with low partial pressure
of oxygen (pO2) levels can result in resistance to radiotherapy, thus causing
local failure. Therefore, it would be desirable to noninvasively measure pO2
levels in the tumor before, during, and after treatment to better customize
therapy and follow treatment response. Several techniques used in preclinical and
clinical studies to obtain the pO2 status of tissue, such as dynamic
contrast-enhanced magnetic resonance imaging, blood oxygen level-dependent
imaging, and electron paramagnetic resonance imaging, are reviewed. Furthermore,
the ability to hyperpolarize specific metabolic substrates that are isotopically
labeled with (13)C coupled with magnetic resonance spectroscopy enables
noninvasive imaging of tissue metabolism, such as glycolysis.