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10.1074/jbc.M113.515296

http://scihub22266oqcxt.onion/10.1074/jbc.M113.515296
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C4059150!4059150!24782308
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suck abstract from ncbi


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pmid24782308      J+Biol+Chem 2014 ; 289 (24): 17087-99
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  • Differential Interaction of Tomosyn with Syntaxin and SNAP25 Depends on Domains in the WD40 ?-Propeller Core and Determines Its Inhibitory Activity* #MMPMID24782308
  • Bielopolski N; Lam AD; Bar-On D; Sauer M; Stuenkel EL; Ashery U
  • J Biol Chem 2014[Jun]; 289 (24): 17087-99 PMID24782308show ga
  • Background: Tomosyn's WD40 domain affects its ability to inhibit exocytosis.Results: Unstructured loops in the WD40 domain are involved in tomosyn's diffusion and organization on the plasma membrane.Conclusion: These key loops mediate tomosyn's binding to the SNARE protein SNAP25.Significance: Novel findings regarding tomosyn's membranal distribution and interactions shed new light on regulation of exocytosis by the SNARE complex and tomosyn.
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