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10.1074/jbc.M114.563114

http://scihub22266oqcxt.onion/10.1074/jbc.M114.563114
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C4059144!4059144!24798340
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suck abstract from ncbi


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pmid24798340      J+Biol+Chem 2014 ; 289 (24): 17020-9
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  • Nuclear Factor E2-related Factor-2 (Nrf2) Is Required for NLRP3 and AIM2 Inflammasome Activation* #MMPMID24798340
  • Zhao C; Gillette DD; Li X; Zhang Z; Wen H
  • J Biol Chem 2014[Jun]; 289 (24): 17020-9 PMID24798340show ga
  • Background: A subgroup of the NLR (nucleotide binding domain, leucine-rich repeat-containing) proteins and a non-NLR protein AIM2 are key mediators of the inflammasome.Results: Cells lacking Nrf2 are defective in the activation of the NLRP3 and AIM2 inflammasome but not the NLRC4 inflammasome.Conclusion: Nrf2 is an essential mediator of NLRP3 and AIM2 inflammasome activation.Significance: Nrf2 plays a proinflammatory role by enhancing inflammasome activation.
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