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10.1186/1471-2474-15-184 http://scihub22266oqcxt.onion/10.1186/1471-2474-15-184 C4059090!4059090!24885217     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Musculoskelet+Disord 2014 ; 15 (ä): 184 Nephropedia Template TP {{tp|p=24885217|t=2014. Influence of antiTNF-alpha antibody treatment on fracture healing under chronic inflammation |pdf=|usr=}}{{24885217}} gab.com Text Influence of antiTNF-alpha antibody treatment on fracture healing under chronic inflammation JO: BMC Musculoskelet Disord http://www.kidney.de/pget.php?&tw=1&pmid=24885217 #FOAvip Background: The overexpression of tumor necrosis factor (TNF)-? leads to systemic as well as local loss of bone and cartilage and is also an important regulator during fracture healing. In this study, we investigate how TNF-? inhibition using a targeted monoclonal antibody affects fracture healing in a TNF-? driven animal model of human rheumatoid arthritis (RA) and elucidate the question whether enduring the anti TNF-? therapy after trauma is beneficial or not. Methods: A standardized femur fracture was applied to wild type and human TNF-? transgenic mice (hTNFtg mice), which develop an RA-like chronic polyarthritis. hTNFtg animals were treated with anti-TNF antibody (Infliximab) during the fracture repair. Untreated animals served as controls. Fracture healing was evaluated after 14 and 28 days of treatment by clinical assessment, biomechanical testing and histomorphometry. Results: High levels of TNF-? influence fracture healing negatively, lead to reduced cartilage and more soft tissue in the callus as well as decreased biomechanical bone stability. Blocking TNF-? in hTNFtg mice lead to similar biomechanical and histomorphometrical properties as in wild type. Conclusions: High levels of TNF-? during chronic inflammation have a negative impact on fracture healing. Our data suggest that TNF-? inhibition by an anti-TNF antibody does not interfere with fracture healing. Twit Text FOAVip Influence of antiTNF-alpha antibody treatment on fracture healing under chronic inflammation ????BMC Musculoskelet Disord http://www.kidney.de/pget.php?&tw=1&pmid=24885217 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24885217 #FOAvip English Wikipedia <ref>{{Cite pmid|24885217}}</ref> Influence of antiTNF-alpha antibody treatment on fracture healing under chronic inflammation #MMPMID24885217 Timmen M; Hidding H; Wieskötter B; Baum W; Pap T; Raschke MJ; Schett G; Zwerina J; Stange R BMC Musculoskelet Disord 2014[]; 15 (ä): 184 PMID24885217show ga Background: The overexpression of tumor necrosis factor (TNF)-? leads to systemic as well as local loss of bone and cartilage and is also an important regulator during fracture healing. In this study, we investigate how TNF-? inhibition using a targeted monoclonal antibody affects fracture healing in a TNF-? driven animal model of human rheumatoid arthritis (RA) and elucidate the question whether enduring the anti TNF-? therapy after trauma is beneficial or not. Methods: A standardized femur fracture was applied to wild type and human TNF-? transgenic mice (hTNFtg mice), which develop an RA-like chronic polyarthritis. hTNFtg animals were treated with anti-TNF antibody (Infliximab) during the fracture repair. Untreated animals served as controls. Fracture healing was evaluated after 14 and 28 days of treatment by clinical assessment, biomechanical testing and histomorphometry. Results: High levels of TNF-? influence fracture healing negatively, lead to reduced cartilage and more soft tissue in the callus as well as decreased biomechanical bone stability. Blocking TNF-? in hTNFtg mice lead to similar biomechanical and histomorphometrical properties as in wild type. Conclusions: High levels of TNF-? during chronic inflammation have a negative impact on fracture healing. Our data suggest that TNF-? inhibition by an anti-TNF antibody does not interfere with fracture healing. äInfluence of antiTNF-alpha antibody treatment on fracture healing unde(epmc).pdf DeepDyve Pubget Overpricing