Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.cmet.2014.03.005 http://scihub22266oqcxt.onion/10.1016/j.cmet.2014.03.005 C4058888!4058888!24703698     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2014 ; 19 (4): 667-81 Nephropedia Template TP {{tp|p=24703698|t=2014. Glucagon Regulates Hepatic Kisspeptin1 to Impair Insulin Secretion |pdf=|usr=}}{{24703698}} gab.com Text Glucagon Regulates Hepatic Kisspeptin1 to Impair Insulin Secretion JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=24703698 #FOAvip Early in the pathogenesis of Type 2 diabetes mellitus (T2DM), dysregulated glucagon secretion from pancreatic ?-cells occurs prior to impaired glucose stimulated insulin secretion (GSIS) from ?-cells. However, whether hyperglucagonemia is causally linked to ?-cell dysfunction remains unclear. Here we show that glucagon stimulates via cAMP-PKA-CREB signaling hepatic production of the neuropeptide kisspeptin1, which acts on ?-cells to suppress GSIS. Synthetic kisspeptin suppresses GSIS in vivo in mice and from isolated islets in a kisspeptin1 receptor-dependent manner. Kisspeptin1 is increased in livers and in serum from humans with T2DM and from mouse models of diabetes mellitus. Importantly, liver Kiss1 knockdown in hyperglucagonemic, glucose intolerant high fat diet fed and Leprdb/db mice augments GSIS and improves glucose tolerance. These observations indicate a hormonal circuit between the liver and the endocrine pancreas in glycemia regulation and suggest in T2DM a sequential link between hyperglucagonemia via hepatic kisspeptin1 to impaired insulin secretion. Twit Text FOAVip Glucagon Regulates Hepatic Kisspeptin1 to Impair Insulin Secretion ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=24703698 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24703698 #FOAvip English Wikipedia <ref>{{Cite pmid|24703698}}</ref> Glucagon Regulates Hepatic Kisspeptin1 to Impair Insulin Secretion #MMPMID24703698 Song WJ; Mondal P; Wolfe A; Alonso LC; Stamateris R; Ong BWT; Lim OC; Yang KS; Radovick S; Novaira HF; Farber EA; Farber CR; Turner SD; Hussain MA Cell Metab 2014[Apr]; 19 (4): 667-81 PMID24703698show ga Early in the pathogenesis of Type 2 diabetes mellitus (T2DM), dysregulated glucagon secretion from pancreatic ?-cells occurs prior to impaired glucose stimulated insulin secretion (GSIS) from ?-cells. However, whether hyperglucagonemia is causally linked to ?-cell dysfunction remains unclear. Here we show that glucagon stimulates via cAMP-PKA-CREB signaling hepatic production of the neuropeptide kisspeptin1, which acts on ?-cells to suppress GSIS. Synthetic kisspeptin suppresses GSIS in vivo in mice and from isolated islets in a kisspeptin1 receptor-dependent manner. Kisspeptin1 is increased in livers and in serum from humans with T2DM and from mouse models of diabetes mellitus. Importantly, liver Kiss1 knockdown in hyperglucagonemic, glucose intolerant high fat diet fed and Leprdb/db mice augments GSIS and improves glucose tolerance. These observations indicate a hormonal circuit between the liver and the endocrine pancreas in glycemia regulation and suggest in T2DM a sequential link between hyperglucagonemia via hepatic kisspeptin1 to impaired insulin secretion. äGlucagon Regulates Hepatic Kisspeptin1 to Impair Insulin Secretion (epmc).pdf DeepDyve Pubget Overpricing