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10.1016/j.bbadis.2013.11.004 http://scihub22266oqcxt.onion/10.1016/j.bbadis.2013.11.004 C4058823!4058823!24240090     free     free     free       Biochim+Biophys+Acta 2014 ; 1842 (6): 758-64 Nephropedia Template TP {{tp|p=24240090|t=2014. Human Diseases of the SSU Processome |pdf=|usr=}}{{24240090}} gab.com Text Human Diseases of the SSU Processome JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24240090 #FOAvip Ribosomes are the cellular machines responsible for protein synthesis. Ribosome biogenesis, the production of ribosomes, is a complex process involving pre-ribosomal RNA (rRNA) cleavages and modifications as well as ribosomal protein assembly around the rRNAs to create the functional ribosome. The SSU processome is a large ribonucleoprotein (RNP) in eukaryotes required for the assembly of the small subunit (SSU) of the ribosome as well as for the maturation of the 18S rRNA. Despite the fundamental nature of the SSU processome to the survival of any eukaryotic cell, mutations in SSU processome components have been implicated in human diseases. Three SSU processome components and their related human diseases will be explored in this review: hUTP4/Cirhin, implicated in North American Indian Childhood Cirrhosis (NAIC); UTP14, implicated in infertility, ovarian cancer, and scleroderma; and EMG1, implicated in Bowen-Conradi Syndrome (BCS). Diseases with suggestive, though inconclusive, evidence for the involvement of the SSU processome in their pathogenesis are also discussed, including a novel putative ribosomopathy. Twit Text FOAVip Human Diseases of the SSU Processome ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24240090 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24240090 #FOAvip English Wikipedia <ref>{{Cite pmid|24240090}}</ref> Human Diseases of the SSU Processome #MMPMID24240090 Sondalle SB; Baserga SJ Biochim Biophys Acta 2014[Jun]; 1842 (6): 758-64 PMID24240090show ga Ribosomes are the cellular machines responsible for protein synthesis. Ribosome biogenesis, the production of ribosomes, is a complex process involving pre-ribosomal RNA (rRNA) cleavages and modifications as well as ribosomal protein assembly around the rRNAs to create the functional ribosome. The SSU processome is a large ribonucleoprotein (RNP) in eukaryotes required for the assembly of the small subunit (SSU) of the ribosome as well as for the maturation of the 18S rRNA. Despite the fundamental nature of the SSU processome to the survival of any eukaryotic cell, mutations in SSU processome components have been implicated in human diseases. Three SSU processome components and their related human diseases will be explored in this review: hUTP4/Cirhin, implicated in North American Indian Childhood Cirrhosis (NAIC); UTP14, implicated in infertility, ovarian cancer, and scleroderma; and EMG1, implicated in Bowen-Conradi Syndrome (BCS). Diseases with suggestive, though inconclusive, evidence for the involvement of the SSU processome in their pathogenesis are also discussed, including a novel putative ribosomopathy. äHuman Diseases of the SSU Processome (epmc).pdf DeepDyve Pubget Overpricing