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2014 ; 2014
(ä): 901428
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Identification of microRNAs as potential biomarker for gastric cancer by system
biological analysis
#MMPMID24982912
Yan W
; Wang S
; Sun Z
; Lin Y
; Sun S
; Chen J
; Chen W
Biomed Res Int
2014[]; 2014
(ä): 901428
PMID24982912
show ga
Gastric cancers (GC) have the high morbidity and mortality rates worldwide and
there is a need to identify sufficiently sensitive biomarkers for GC. MicroRNAs
(miRNAs) could be promising potential biomarkers for GC diagnosis. We employed a
systematic and integrative bioinformatics framework to identify GC-related
microRNAs from the public microRNA and mRNA expression dataset generated by
RNA-seq technology. The performance of the 17 candidate miRNAs was evaluated by
hierarchal clustering, ROC analysis, and literature mining. Fourteen have been
found to be associated with GC and three microRNAs (miR-211, let-7b, and miR-708)
were for the first time reported to associate with GC and may be used for
diagnostic biomarkers for GC.