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10.1155/2014/504808 http://scihub22266oqcxt.onion/10.1155/2014/504808 C4058521!4058521!24982885     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2014 ; 2014 (ä): ä Nephropedia Template TP {{tp|p=24982885|t=2014. Roles of Renal Proximal Tubule Transport in Acid/Base Balance and Blood Pressure Regulation |pdf=|usr=}}{{24982885}} gab.com Text Roles of Renal Proximal Tubule Transport in Acid/Base Balance and Blood Pressure Regulation JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=24982885 #FOAvip Sodium-coupled bicarbonate absorption from renal proximal tubules (PTs) plays a pivotal role in the maintenance of systemic acid/base balance. Indeed, mutations in the Na+-HCO3? cotransporter NBCe1, which mediates a majority of bicarbonate exit from PTs, cause severe proximal renal tubular acidosis associated with ocular and other extrarenal abnormalities. Sodium transport in PTs also plays an important role in the regulation of blood pressure. For example, PT transport stimulation by insulin may be involved in the pathogenesis of hypertension associated with insulin resistance. Type 1 angiotensin (Ang) II receptors in PT are critical for blood pressure homeostasis. Paradoxically, the effects of Ang II on PT transport are known to be biphasic. Unlike in other species, however, Ang II is recently shown to dose-dependently stimulate human PT transport via nitric oxide/cGMP/ERK pathway, which may represent a novel therapeutic target in human hypertension. In this paper, we will review the physiological and pathophysiological roles of PT transport. Twit Text FOAVip Roles of Renal Proximal Tubule Transport in Acid/Base Balance and Blood Pressure Regulation ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=24982885 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24982885 #FOAvip English Wikipedia <ref>{{Cite pmid|24982885}}</ref> Roles of Renal Proximal Tubule Transport in Acid/Base Balance and Blood Pressure Regulation #MMPMID24982885 Nakamura M; Shirai A; Yamazaki O; Satoh N; Suzuki M; Horita S; Yamada H; Seki G Biomed Res Int 2014[]; 2014 (ä): ä PMID24982885show ga Sodium-coupled bicarbonate absorption from renal proximal tubules (PTs) plays a pivotal role in the maintenance of systemic acid/base balance. Indeed, mutations in the Na+-HCO3? cotransporter NBCe1, which mediates a majority of bicarbonate exit from PTs, cause severe proximal renal tubular acidosis associated with ocular and other extrarenal abnormalities. Sodium transport in PTs also plays an important role in the regulation of blood pressure. For example, PT transport stimulation by insulin may be involved in the pathogenesis of hypertension associated with insulin resistance. Type 1 angiotensin (Ang) II receptors in PT are critical for blood pressure homeostasis. Paradoxically, the effects of Ang II on PT transport are known to be biphasic. Unlike in other species, however, Ang II is recently shown to dose-dependently stimulate human PT transport via nitric oxide/cGMP/ERK pathway, which may represent a novel therapeutic target in human hypertension. In this paper, we will review the physiological and pathophysiological roles of PT transport. äRoles of Renal Proximal Tubule Transport in Acid/Base Balance and Bloo(epmc).pdf DeepDyve Pubget Overpricing