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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Calcium 2014 ; 55 (6): 317-24 Nephropedia Template TP
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CALCIUM SIGNALING AND THE SECRETORY ACTIVITY OF BILE DUCT EPITHELIA #MMPMID24612866
Amaya MJ; Nathanson MH
Cell Calcium 2014[Jun]; 55 (6): 317-24 PMID24612866show ga
Cytosolic calcium (Cai2+) is a second messenger that is important for the regulation of secretion in many types of tissues. Bile duct epithelial cells, or cholangiocytes, are polarized epithelia that line the biliary tree in liver and are responsible for secretion of bicarbonate and other solutes into bile. Cai2+ signaling plays an important role in the regulation of secretion by cholangiocytes, and this review discusses the machinery involved in the formation of Ca2+ signals in cholangiocytes, along with the evidence that these signals regulate ductular secretion. Finally, this review discusses the evidence that impairments in cholangiocyte Ca2+ signaling play a primary role in the pathogenesis of cholestatic disorders, in which hepatic bile secretion is impaired.