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Small cell lung cancer cells express the late stage gBK tumor antigen: a possible immunotarget for the terminal disease |pdf=|usr=}}{{24936214 }} gab.com Text Small cell lung cancer cells express the late stage gBK tumor antigen: a possible immunotarget for the terminal disease JO: Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=24936214 #FOAvip Big Potassium (BK) ion channels have several splice variants. One splice variant initially described within human glioma cells is called the glioma BK channel (gBK). Using a gBK-specific antibody, we detected gBK within three human small cell lung cancer (SCLC) lines. Electrophysiology revealed that functional membrane channels were found on the SCLC cells. Prolonged exposure to BK channel activators caused the SCLC cells to swell within 20 minutes and resulted in their death within five hours. Transduction of BK-negative HEK cells with gBK produced functional gBK channels. Quantitative RT-PCR analysis using primers specific for gBK, but not with a lung-specific marker, Sox11, confirmed that advanced, late-stage human SCLC tissues strongly expressed gBK mRNA. Normal human lung tissue and early, lower stage SCLC resected tissues very weakly expressed this transcript. Immunofluorescence using the anti-gBK antibody confirmed that SCLC cells taken at the time of the autopsy intensely displayed this protein. gBK may represent a late-stage marker for SCLC. HLA-A*0201 restricted human CTL were generated in vitro using gBK peptide pulsed dendritic cells. The exposure of SCLC cells to interferon-? (IFN-?) increased the expression of HLA; these treated cells were killed by the CTL better than non-IFN-? treated cells even though the IFN-? treated SCLC cells displayed diminished gBK protein expression. Prolonged incubation with recombinant IFN-? slowed the in vitro growth and prevented transmigration of the SCLC cells, suggesting IFN-? might inhibit tumor growth in vivo. Immunotherapy targeting gBK might impede advancement to the terminal stage of SCLC via two pathways. Twit Text FOAVip Small cell lung cancer cells express the late stage gBK tumor antigen: a possible immunotarget for the terminal disease ????Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=24936214 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24936214 #FOAvip English Wikipedia <ref>{{Cite pmid|24936214 }}</ref> Small cell lung cancer cells express the late stage gBK tumor antigen: a possible immunotarget for the terminal disease #MMPMID24936214 Hoa NT ; Ge L ; Tajhya RB ; Beeton C ; Cornforth AN ; Abolhoda A ; Lambrecht N ; DaCosta-Iyer M ; Ouyang Y ; Mai AP ; Hong E ; Shon J ; Hickey MJ ; Erickson KL ; Kruse CA ; Jadus MR Am J Transl Res 2014[]; 6 (3 ): 188-205 PMID24936214 show ga Big Potassium (BK) ion channels have several splice variants. One splice variant initially described within human glioma cells is called the glioma BK channel (gBK). Using a gBK-specific antibody, we detected gBK within three human small cell lung cancer (SCLC) lines. Electrophysiology revealed that functional membrane channels were found on the SCLC cells. Prolonged exposure to BK channel activators caused the SCLC cells to swell within 20 minutes and resulted in their death within five hours. Transduction of BK-negative HEK cells with gBK produced functional gBK channels. Quantitative RT-PCR analysis using primers specific for gBK, but not with a lung-specific marker, Sox11, confirmed that advanced, late-stage human SCLC tissues strongly expressed gBK mRNA. Normal human lung tissue and early, lower stage SCLC resected tissues very weakly expressed this transcript. Immunofluorescence using the anti-gBK antibody confirmed that SCLC cells taken at the time of the autopsy intensely displayed this protein. gBK may represent a late-stage marker for SCLC. HLA-A*0201 restricted human CTL were generated in vitro using gBK peptide pulsed dendritic cells. The exposure of SCLC cells to interferon-? (IFN-?) increased the expression of HLA; these treated cells were killed by the CTL better than non-IFN-? treated cells even though the IFN-? treated SCLC cells displayed diminished gBK protein expression. Prolonged incubation with recombinant IFN-? slowed the in vitro growth and prevented transmigration of the SCLC cells, suggesting IFN-? might inhibit tumor growth in vivo. Immunotherapy targeting gBK might impede advancement to the terminal stage of SCLC via two pathways. äSmall cell lung cancer cells express the late stage gBK tumor antigen:(epmc).pdf DeepDyve Pubget Overpricing