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2014 ; 2014
(ä): 482438
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Biological pathways and potential targets for prevention and therapy of chronic
allograft nephropathy
#MMPMID24971332
Shrestha BM
; Haylor J
Biomed Res Int
2014[]; 2014
(ä): 482438
PMID24971332
show ga
Renal transplantation (RT) is the best option for patients with end-stage renal
disease, but the half-life is limited to a decade due to progressive
deterioration of renal function and transplant failure from chronic allograft
nephropathy (CAN), which is the leading cause of transplant loss. Extensive
research has been done to understand the pathogenesis, the biological pathways of
fibrogenesis, and potential therapeutic targets for the prevention and treatment
of CAN. Despite the advancements in the immunosuppressive agents and patient
care, CAN continues to remain an unresolved problem in renal transplantation. The
aim of this paper is to undertake a comprehensive review of the literature on the
pathogenesis, biological pathways of RT fibrogenesis, and potential therapeutic
targets for the prevention and therapy of CAN.