Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1155/2014/782625 http://scihub22266oqcxt.onion/10.1155/2014/782625 C4058256!4058256!24971350     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2014 ; 2014 (ä): ä Nephropedia Template TP {{tp|p=24971350|t=2014. High Glucose Induces Sumoylation of Smad4 via SUMO2/3 in Mesangial Cells |pdf=|usr=}}{{24971350}} gab.com Text High Glucose Induces Sumoylation of Smad4 via SUMO2/3 in Mesangial Cells JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=24971350 #FOAvip Recent studies have shown that sumoylation is a posttranslational modification involved in regulation of the transforming growth factor-? (TGF-?) signaling pathway, which plays a critical role in renal fibrosis in diabetic nephropathy (DN). However, the role of sumoylation in the regulation of TGF-? signaling in DN is still unclear. In the present study, we investigated the expression of SUMO (SUMO1 and SUMO2/3) and Smad4 and the interaction between SUMO and Smad4 in cultured rat mesangial cells induced by high glucose. We found that SUMO1 and SUMO2/3 expression was significantly increased in the high glucose groups compared to the normal group (P < 0.05). Smad4 and fibronectin (FN) levels were also increased in the high glucose groups in a dose-dependent manner. Coimmunoprecipitation and confocal laser scanning revealed that Smad4 interacted and colocalized with SUMO2/3, but not with SUMO1 in mesangial cells. Sumoylation (SUMO2/3) of Smad4 under high glucose condition was strongly enhanced compared to normal control (P < 0.05). These results suggest that high glucose may activate TGF-?/Smad signaling through sumoylation of Samd4 by SUMO2/3 in mesangial cells. Twit Text FOAVip High Glucose Induces Sumoylation of Smad4 via SUMO2/3 in Mesangial Cells ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=24971350 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24971350 #FOAvip English Wikipedia <ref>{{Cite pmid|24971350}}</ref> High Glucose Induces Sumoylation of Smad4 via SUMO2/3 in Mesangial Cells #MMPMID24971350 Zhou X; Gao C; Huang W; Yang M; Chen G; Jiang L; Gou F; Feng H; Ai N; Xu Y Biomed Res Int 2014[]; 2014 (ä): ä PMID24971350show ga Recent studies have shown that sumoylation is a posttranslational modification involved in regulation of the transforming growth factor-? (TGF-?) signaling pathway, which plays a critical role in renal fibrosis in diabetic nephropathy (DN). However, the role of sumoylation in the regulation of TGF-? signaling in DN is still unclear. In the present study, we investigated the expression of SUMO (SUMO1 and SUMO2/3) and Smad4 and the interaction between SUMO and Smad4 in cultured rat mesangial cells induced by high glucose. We found that SUMO1 and SUMO2/3 expression was significantly increased in the high glucose groups compared to the normal group (P < 0.05). Smad4 and fibronectin (FN) levels were also increased in the high glucose groups in a dose-dependent manner. Coimmunoprecipitation and confocal laser scanning revealed that Smad4 interacted and colocalized with SUMO2/3, but not with SUMO1 in mesangial cells. Sumoylation (SUMO2/3) of Smad4 under high glucose condition was strongly enhanced compared to normal control (P < 0.05). These results suggest that high glucose may activate TGF-?/Smad signaling through sumoylation of Samd4 by SUMO2/3 in mesangial cells. äHigh Glucose Induces Sumoylation of Smad4 via SUMO2/3 in Mesangial Cel(epmc).pdf DeepDyve Pubget Overpricing