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suck abstract from ncbi


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pmid24955182      Int+J+Clin+Exp+Med 2014 ; 7 (4): 1059-63
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  • Serum levels of thrombotic markers in patients with acute myocardial infarction #MMPMID24955182
  • Islam S; Yakout SM; Daghri NMA; Alhomida AS; Khan HA
  • Int J Clin Exp Med 2014[]; 7 (4): 1059-63 PMID24955182show ga
  • Tissue plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) have pro- and anti-fibrinolytic activities respectively. The net fibrinolytic activity is mainly determined by the balance between TPA and PAI-1 levels. Considering the important role of these markers in thrombotic pathway, we determined the levels of TPA and PAI-1 in sera of 50 AMI patients, 100 patients with associated risk factors (dyslipidemia and high blood pressure) and 100 healthy controls. The findings showed significantly high levels of TPA and PAI-1 in AMI patients as compared to control subjects. Both these markers were only non-significantly increased in the risk group. There was no correlation between body mass index and these markers however TPA and PAI-1 were significantly correlated with age and systolic blood pressure, respectively. In conclusion, a combination of these markers could provide a useful tool to assess the prognosis of AMI.
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