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10.1001/jamapsychiatry.2013.4291 http://scihub22266oqcxt.onion/10.1001/jamapsychiatry.2013.4291 C4057796!4057796!24499927     free     free     free       JAMA+Psychiatry 2014 ; 71 (4): 454-6 Nephropedia Template TP {{tp|p=24499927|t=2014. Epigenetic Mechanisms of Depression |pdf=|usr=}}{{24499927}} gab.com Text Epigenetic Mechanisms of Depression JO: JAMA Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=24499927 #FOAvip Growing evidence supports the hypothesis that epigenetics is a key mechanism through which environmental exposures interact with an individual?s genetic constitution to determine risk for depression throughout life.1 Epigenetics, in its broadest meaning, refers to stable changes in gene expression that are mediated via altered chromatin structure without modification of DNA sequence. According to this hypothesis, severe stress triggers changes?in vulnerable individuals?in chromatin structure at particular genomic loci in the brain?s limbic regions, which drive sustained changes in gene expression that contribute to episodes of depression. A corollary of this hypothesis is that such stress-induced epigenetic modifications also occur early in life and help determine an individual?s lifetime vulnerability or resistance to subsequent stressful events. Twit Text FOAVip Epigenetic Mechanisms of Depression ????JAMA Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=24499927 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24499927 #FOAvip English Wikipedia <ref>{{Cite pmid|24499927}}</ref> Epigenetic Mechanisms of Depression #MMPMID24499927 Nestler EJ JAMA Psychiatry 2014[Apr]; 71 (4): 454-6 PMID24499927show ga Growing evidence supports the hypothesis that epigenetics is a key mechanism through which environmental exposures interact with an individual?s genetic constitution to determine risk for depression throughout life.1 Epigenetics, in its broadest meaning, refers to stable changes in gene expression that are mediated via altered chromatin structure without modification of DNA sequence. According to this hypothesis, severe stress triggers changes?in vulnerable individuals?in chromatin structure at particular genomic loci in the brain?s limbic regions, which drive sustained changes in gene expression that contribute to episodes of depression. A corollary of this hypothesis is that such stress-induced epigenetic modifications also occur early in life and help determine an individual?s lifetime vulnerability or resistance to subsequent stressful events. äEpigenetic Mechanisms of Depression (epmc).pdf DeepDyve Pubget Overpricing