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10.3390/ijms15058713 http://scihub22266oqcxt.onion/10.3390/ijms15058713 C4057755!4057755!24837835     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2014 ; 15 (5): 8713-42 Nephropedia Template TP {{tp|p=24837835|t=2014. Role of Mitochondria in Nonalcoholic Fatty Liver Disease |pdf=|usr=}}{{24837835}} gab.com Text Role of Mitochondria in Nonalcoholic Fatty Liver Disease JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=24837835 #FOAvip Nonalcoholic fatty liver disease (NAFLD) affects about 30% of the general population in the United States and includes a spectrum of disease that includes simple steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Significant insight has been gained into our understanding of the pathogenesis of NALFD; however the key metabolic aberrations underlying lipid accumulation in hepatocytes and the progression of NAFLD remain to be elucidated. Accumulating and emerging evidence indicate that hepatic mitochondria play a critical role in the development and pathogenesis of steatosis and NAFLD. Here, we review studies that document a link between the pathogenesis of NAFLD and hepatic mitochondrial dysfunction with particular focus on new insights into the role of impaired fatty acid oxidation, the transcription factor peroxisome proliferator-activated receptor-? coactivator-1? (PGC-1?), and sirtuins in development and progression of NAFLD. Twit Text FOAVip Role of Mitochondria in Nonalcoholic Fatty Liver Disease ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=24837835 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24837835 #FOAvip English Wikipedia <ref>{{Cite pmid|24837835}}</ref> Role of Mitochondria in Nonalcoholic Fatty Liver Disease #MMPMID24837835 Nassir F; Ibdah JA Int J Mol Sci 2014[May]; 15 (5): 8713-42 PMID24837835show ga Nonalcoholic fatty liver disease (NAFLD) affects about 30% of the general population in the United States and includes a spectrum of disease that includes simple steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Significant insight has been gained into our understanding of the pathogenesis of NALFD; however the key metabolic aberrations underlying lipid accumulation in hepatocytes and the progression of NAFLD remain to be elucidated. Accumulating and emerging evidence indicate that hepatic mitochondria play a critical role in the development and pathogenesis of steatosis and NAFLD. Here, we review studies that document a link between the pathogenesis of NAFLD and hepatic mitochondrial dysfunction with particular focus on new insights into the role of impaired fatty acid oxidation, the transcription factor peroxisome proliferator-activated receptor-? coactivator-1? (PGC-1?), and sirtuins in development and progression of NAFLD. äRole of Mitochondria in Nonalcoholic Fatty Liver Disease (epmc).pdf DeepDyve Pubget Overpricing