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10.3390/ijms15058037 http://scihub22266oqcxt.onion/10.3390/ijms15058037 C4057717!4057717 !24815066     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24815066 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2014 ; 15 (5 ): 8037-48 Nephropedia Template TP {{tp|p=24815066 |t=2014. SHSST cyclodextrin complex prevents the fibrosis effect on CCl?-induced cirrhotic cardiomyopathy in rats through TGF-? pathway inhibition effects |pdf=|usr=}}{{24815066 }} gab.com Text SHSST cyclodextrin complex prevents the fibrosis effect on CCl -induced cirrhotic cardiomyopathy in rats through TGF- pathway inhibition effects JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=24815066 #FOAvip Patients with liver cirrhosis also have subtle cardiac structure or function abnormalities. This cardiac dysfunction commonly occurs in 56% of waiting orthotopic liver transplantation (OLT) patients and is defined as cirrhotic cardiomyopathy (CCM). Up to now, there is no standard treatment because CCM does not have a solidly established diagnosis and is based on high clinical suspicion. The liver function of CCM is particularly limited, making patients vulnerable to more drug treatments. Here, we use silymarin (100 mg/kg/day), baicalein (30 mg/kg/day), San Huang Shel Shin Tang (SHSST, 30 mg/kg/day) and ?-cyclodextrin modified SHSST (SHSSTc, 30 and 300 mg/kg/day) treatments for a CCl4-induced CCM rat model. The results show that silymarin, baicalein and SHSST treatments can only slightly reduce the collagen accumulation in CCM rat hearts. However, SHSSTc treatment protects the heart in CCM and significantly inhibits collagen acumination and the fibrosis regulating transforming growth factor-? (TGF-?) pathway expression. SHSSTc treatments further reduced the heart weight and the ratio between left ventricular weight (LVW) and tibia length (TL). This experimental data show that water solubility improved ?-cyclodextrin modified Chinese herbal medicine formula (SHSSTc) can provide an excellent heart protection effect through TGF-? pathway inhibition. Twit Text FOAVip SHSST cyclodextrin complex prevents the fibrosis effect on CCl -induced cirrhotic cardiomyopathy in rats through TGF- pathway inhibition effects ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=24815066 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24815066 #FOAvip English Wikipedia <ref>{{Cite pmid|24815066 }}</ref> SHSST cyclodextrin complex prevents the fibrosis effect on CCl?-induced cirrhotic cardiomyopathy in rats through TGF-? pathway inhibition effects #MMPMID24815066 Yang CH ; Ting WJ ; Day CH ; Ju DT ; Yeh YL ; Chung LC ; Tsai FJ ; Tsai CH ; Tsai Y ; Huang CY Int J Mol Sci 2014[May]; 15 (5 ): 8037-48 PMID24815066 show ga Patients with liver cirrhosis also have subtle cardiac structure or function abnormalities. This cardiac dysfunction commonly occurs in 56% of waiting orthotopic liver transplantation (OLT) patients and is defined as cirrhotic cardiomyopathy (CCM). Up to now, there is no standard treatment because CCM does not have a solidly established diagnosis and is based on high clinical suspicion. The liver function of CCM is particularly limited, making patients vulnerable to more drug treatments. Here, we use silymarin (100 mg/kg/day), baicalein (30 mg/kg/day), San Huang Shel Shin Tang (SHSST, 30 mg/kg/day) and ?-cyclodextrin modified SHSST (SHSSTc, 30 and 300 mg/kg/day) treatments for a CCl4-induced CCM rat model. The results show that silymarin, baicalein and SHSST treatments can only slightly reduce the collagen accumulation in CCM rat hearts. However, SHSSTc treatment protects the heart in CCM and significantly inhibits collagen acumination and the fibrosis regulating transforming growth factor-? (TGF-?) pathway expression. SHSSTc treatments further reduced the heart weight and the ratio between left ventricular weight (LVW) and tibia length (TL). This experimental data show that water solubility improved ?-cyclodextrin modified Chinese herbal medicine formula (SHSSTc) can provide an excellent heart protection effect through TGF-? pathway inhibition. |Animals [MESH] |Antioxidants/therapeutic use [MESH] |Carbon Tetrachloride [MESH] |Cardiomyopathies/chemically induced/*drug therapy/metabolism/*pathology [MESH] |Drug Carriers/chemistry [MESH] |Drugs, Chinese Herbal/administration & dosage/chemistry/*therapeutic use [MESH] |Flavanones/therapeutic use [MESH] |Heart/drug effects [MESH] |Liver Cirrhosis/chemically induced/*complications [MESH] |Liver/drug effects/pathology [MESH] |Myocardium/metabolism/*pathology [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Signal Transduction/drug effects [MESH] |Silymarin/therapeutic use [MESH] |Transforming Growth Factor beta/*metabolism [MESH]SHSST cyclodextrin complex prevents the fibrosis effect on CCl?-induce(epmc).pdf DeepDyve Pubget Overpricing