Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24932457
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Diabetes+Metab+Disord
2014 ; 13
(ä): 60
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Mitochondrial dysfunction in obesity: potential benefit and mechanism of
Co-enzyme Q10 supplementation in metabolic syndrome
#MMPMID24932457
Alam MA
; Rahman MM
J Diabetes Metab Disord
2014[]; 13
(ä): 60
PMID24932457
show ga
Co-enzyme Q10 (Co-Q10) is an essential component of the mitochondrial electron
transport chain. Most cells are sensitive to co-enzyme Q10 (Co-Q10) deficiency.
This deficiency has been implicated in several clinical disorders such as heart
failure, hypertension, Parkinson's disease and obesity. The lipid lowering drug
statin inhibits conversion of HMG-CoA to mevalonate and lowers plasma Co-Q10
concentrations. However, supplementation with Co-Q10 improves the
pathophysiological condition of statin therapy. Recent evidence suggests that
Co-Q10 supplementation may be useful for the treatment of obesity, oxidative
stress and the inflammatory process in metabolic syndrome. The anti-inflammatory
response and lipid metabolizing effect of Co-Q10 is probably mediated by
transcriptional regulation of inflammation and lipid metabolism. This paper
reviews the evidence showing beneficial role of Co-Q10 supplementation and its
potential mechanism of action on contributing factors of metabolic and
cardiovascular complications.