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2013 ; 13
(4
): 1098-106
Nephropedia Template TP
gab.com Text
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English Wikipedia
Enteroviruses as a possible cause of hypertension, dilated cardiomyopathy (DCM)
and hypertensive heart failure (HHF) in South western Nigeria
#MMPMID24940338
Okonko IO
; Adebiyi AA
; Ogah OS
; Adu FD
Afr Health Sci
2013[Dec]; 13
(4
): 1098-106
PMID24940338
show ga
BACKGROUND: Human enteroviruses have long been associated with various diseases
of man resulting into a wide range of acute symptoms involving the cardiac and
skeletal muscles, central nervous system, pancreas, skin and mucous membranes.
OBJECTIVE: To assess the role of enteroviruses in the etiology of hypertension,
DCM and HHF. METHODS: We obtained stool specimens from 70 subjects comprising 65
patients and 5 controls and isolation was carried out on RD, L20B, HEp-2C and
Vero cell lines and identified by neutralization with standard antisera (RIVM).
Thirty-six enteroviruses were isolated and identified to be Coxsackieviruses-B5,
A9, Echoviruses 1, 6, 7, 9, 11, 12, 22, 30 and Poliovirus type 1 and 3. RESULTS:
Three most frequently occurring enterovirus serotypes which constitute 60.0% of
the 30 NPEV typed and 50.0% of all the isolates were Echoviruses,
Coxsackie-B5-virus and Coxsackievirus-A9. Echoviruses constituted 50.0% of all
the serotypes while Coxsackieviruses-B5 and A9 accounts for the 27.8 % and 5.6%
respectively. Enteroviral isolation rate was higher in age groups 51 years and
above. The percentage of study subjects who had Coxsackie-B5-viruses and
echoviruses was significantly (P<0.05) higher in cases of hypertension, HHF and
DCM than in control subjects. Coxackie-B5-virus, Echovirus-6 and Echovirus-11
were found in both study locations. CONCLUSION: The findings of this study showed
that Enteroviruses may likely be involved in the etiology of hypertension, DCM
and HHF. Further studies would therefore be necessary for the prevention and
control of these diseases.