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Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Science 2014 ; 344 (6180): 1240622 Nephropedia Template TP
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Interneurons from Embryonic Development to Cell-Based Therapy #MMPMID24723614
Southwell DG; Nicholas CR; Basbaum AI; Stryker MP; Kriegstein AR; Rubenstein JL; Alvarez-Buylla A
Science 2014[Apr]; 344 (6180): 1240622 PMID24723614show ga
Many neurologic and psychiatric disorders are marked by imbalances between neural excitation and inhibition. In the cerebral cortex, inhibition is mediated largely by GABAergic (?-aminobutyric acid?secreting) interneurons, a cell type that originates in the embryonic ventral telencephalon and populates the cortex through long-distance tangential migration. Remarkably, when transplanted from embryos or in vitro culture preparations, immature interneurons disperse and integrate into host brain circuits, both in the cerebral cortex and in other regions of the central nervous system. These features make interneuron transplantation a powerful tool for the study of neurodevelopmental processes such as cell specification, cell death, and cortical plasticity. Moreover, interneuron transplantation provides a novel strategy for modifying neural circuits in rodent models of epilepsy, Parkinson?s disease, mood disorders, and chronic pain.