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2014 ; 2014
(ä): 180416
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Sensitivities, specificities, and predictive values of microbiological culture
techniques for the diagnosis of prosthetic joint infection
#MMPMID24963476
Jordan RW
; Smith NA
; Saithna A
; Sprowson AP
; Foguet P
Biomed Res Int
2014[]; 2014
(ä): 180416
PMID24963476
show ga
BACKGROUND: Identifying the microorganism in a prosthetic joint infection is the
key to appropriately targeting antimicrobial treatment. Despite the availability
of various techniques, no single test is considered the definitive gold standard.
AIM: Our aim was to determine the sensitivity, specificity, and positive/negative
predictive values for a variety of culture techniques. METHODS: We performed a
retrospective case series of 219 patients undergoing revision surgery of their
hip or knee replacement between May 2004 and February 2013. The patients were
classified as either infected or noninfected according to criteria set out by the
Musculoskeletal Infection Society. The number and type of samples taken
intraoperatively varied between cases but included tissue samples and fluid sent
in either blood culture vials or sterile containers. RESULTS: The highest
sensitivity was found with blood culture vials (0.85) compared to fluid in
sterile containers (0.26) and tissues samples (0.32). Blood culture vials also
had a better specificity and positive and negative predictive values profile.
CONCLUSION: We conclude that, of the techniques studied, fluid in blood culture
vials had the best profile for the correct identification of microorganisms and
advocate its use.