The function of BAFF on T helper cells in autoimmunity #MMPMID24411564
Chen M; Lin X; Liu Y; Li Q; Deng Y; Liu Z; Brand D; Guo Z; He X; Ryffel B; Zheng SG
Cytokine Growth Factor Rev 2014[Jun]; 25 (3): 301-5 PMID24411564show ga
B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in supporting the survival and proliferation of B cells, regulating class switch recombination as well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic expansion of activated B cells, particularly marginal zone B cells, as well as hypergammaglobulinemia, autoantibody production and immune complex deposition. However, in addition to its effect on B cells, recent work has also demonstrated that BAFF can promote T cell activation, proliferation and differentiation. In this review, we have discussed the recent progress on the function and role of BAFF on T cells and T cell-mediated diseases.