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10.1093/jac/dku047 http://scihub22266oqcxt.onion/10.1093/jac/dku047 C4054983!4054983!24583361     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Antimicrob+Chemother 2014 ; 69 (7): 1830-3 Nephropedia Template TP {{tp|p=24583361|t=2014. Induction of human plasmablasts during infection with antibiotic-resistant nosocomial bacteria |pdf=|usr=}}{{24583361}} gab.com Text Induction of human plasmablasts during infection with antibiotic-resistant nosocomial bacteria JO: J Antimicrob Chemother http://www.kidney.de/pget.php?&tw=1&pmid=24583361 #FOAvip Objectives: Nosocomial pathogens such as Acinetobacter baumannii are a growing public health threat, due in part to their increasing resistance to antibiotics. Since some strains are resistant to all available antibiotics, novel therapies are urgently needed. Plasmablasts are short-lived B cells found in the blood that can be collected and harnessed to produce therapeutic antibodies. We set out to determine whether plasmablasts are induced during infection with A. baumannii and other nosocomial pathogens. Methods: We obtained blood samples from patients infected with antibiotic-resistant nosocomial pathogens, and analysed their plasmablast response by flow cytometry. Results: We observed a strong induction of plasmablasts in patients with antibiotic-resistant A. baumannii infection. Furthermore, plasmablasts were also induced in response to other drug-resistant nosocomial pathogens. Conclusions: These data suggest that plasmablasts may be broadly harnessed to develop therapeutic antibodies to combat otherwise untreatable antibiotic-resistant infections. Twit Text FOAVip Induction of human plasmablasts during infection with antibiotic-resistant nosocomial bacteria ????J Antimicrob Chemother http://www.kidney.de/pget.php?&tw=1&pmid=24583361 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24583361 #FOAvip English Wikipedia <ref>{{Cite pmid|24583361}}</ref> Induction of human plasmablasts during infection with antibiotic-resistant nosocomial bacteria #MMPMID24583361 Band VI; Ibegbu C; Kaur SP; Cagle SM; Trible R; Jones CL; Wang YF; Kraft CS; Ray SM; Wrammert J; Weiss DS J Antimicrob Chemother 2014[Jul]; 69 (7): 1830-3 PMID24583361show ga Objectives: Nosocomial pathogens such as Acinetobacter baumannii are a growing public health threat, due in part to their increasing resistance to antibiotics. Since some strains are resistant to all available antibiotics, novel therapies are urgently needed. Plasmablasts are short-lived B cells found in the blood that can be collected and harnessed to produce therapeutic antibodies. We set out to determine whether plasmablasts are induced during infection with A. baumannii and other nosocomial pathogens. Methods: We obtained blood samples from patients infected with antibiotic-resistant nosocomial pathogens, and analysed their plasmablast response by flow cytometry. Results: We observed a strong induction of plasmablasts in patients with antibiotic-resistant A. baumannii infection. Furthermore, plasmablasts were also induced in response to other drug-resistant nosocomial pathogens. Conclusions: These data suggest that plasmablasts may be broadly harnessed to develop therapeutic antibodies to combat otherwise untreatable antibiotic-resistant infections. äInduction of human plasmablasts during infection with antibiotic-resis(epmc).pdf DeepDyve Pubget Overpricing