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10.1186/gb-2013-14-8-r85

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suck abstract from ncbi


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pmid23972209
      Genome+Biol 2013 ; 14 (8 ): R85
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  • Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits #MMPMID23972209
  • Megraw M ; Mukherjee S ; Ohler U
  • Genome Biol 2013[Aug]; 14 (8 ): R85 PMID23972209 show ga
  • WaRSwap is a randomization algorithm that for the first time provides a practical network motif discovery method for large multi-layer networks, for example those that include transcription factors, microRNAs, and non-regulatory protein coding genes. The algorithm is applicable to systems with tens of thousands of genes, while accounting for critical aspects of biological networks, including self-loops, large hubs, and target rearrangements. We validate WaRSwap on a newly inferred regulatory network from Arabidopsis thaliana, and compare outcomes on published Drosophila and human networks. Specifically, sustained input switches are among the few over-represented circuits across this diverse set of eukaryotes.
  • |*Algorithms [MESH]
  • |*Software [MESH]
  • |Animals [MESH]
  • |Arabidopsis/*genetics/metabolism [MESH]
  • |Computational Biology [MESH]
  • |Drosophila melanogaster/genetics/metabolism [MESH]
  • |Gene Expression Regulation [MESH]
  • |Gene Regulatory Networks [MESH]
  • |Humans [MESH]
  • |MicroRNAs/chemistry/*genetics [MESH]
  • |Molecular Sequence Annotation [MESH]
  • |Nucleic Acid Conformation [MESH]


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