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2014 ; 2014
(ä): ä Nephropedia Template TP
gab.com Text
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English Wikipedia
Treatment of choroidal neovascularisation secondary to membranoproliferative
glomerulonephritis type II with intravitreal ranibizumab
#MMPMID24895384
McCullagh D
; Silvestri G
; Maxwell AP
BMJ Case Rep
2014[Jun]; 2014
(ä): ä PMID24895384
show ga
Membranoproliferative glomerulonephritis type II (MPGN II) is characterised by
electron-dense deposits of complement components in the glomerular basement
membrane and retinal pigment epithelium. Approximately, 10% of affected
individuals develop serious ocular complications similar to age-related macular
degeneration such as choroidal neovascularisation (CNV), which has been managed
with photocoagulation or photodynamic therapy; however, these treatments can
impact visual acuity. We report the case of a 42-year-old woman with MPGN II
presenting with decreased visual acuity and paracentral scotoma in her left eye
due to an extrafoveal choroidal neovascular membrane (growth of new vessels under
the retina). The patient was successfully treated with intravitreal ranibizumab
(Lucentis) with restoration of visual function. This case highlights the
successful management of CNV secondary to MPGN II with the antivascular
endothelial growth factor agent ranibizumab and emphasises the importance of
early referral of patients with MPGN II who are reporting of visual 'distortion'.