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10.1186/gb-2013-14-9-r96 http://scihub22266oqcxt.onion/10.1186/gb-2013-14-9-r96 C4053835!4053835 !24025402     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24025402 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genome+Biol 2013 ; 14 (9 ): R96 Nephropedia Template TP {{tp|p=24025402 |t=2013. An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse |pdf=|usr=}}{{24025402 }} gab.com Text An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse JO: Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=24025402 #FOAvip BACKGROUND: We have used a sensitized ENU mutagenesis screen to produce mouse lines that carry mutations in genes required for epigenetic regulation. We call these lines Modifiers of murine metastable epialleles (Mommes). RESULTS: We report a basic molecular and phenotypic characterization for twenty of the Momme mouse lines, and in each case we also identify the causative mutation. Three of the lines carry a mutation in a novel epigenetic modifier, Rearranged L-myc fusion (Rlf), and one gene, Rap-interacting factor 1 (Rif1), has not previously been reported to be involved in transcriptional regulation in mammals. Many of the other lines are novel alleles of known epigenetic regulators. For two genes, Rlf and Widely-interspaced zinc finger (Wiz), we describe the first mouse mutants. All of the Momme mutants show some degree of homozygous embryonic lethality, emphasizing the importance of epigenetic processes. The penetrance of lethality is incomplete in a number of cases. Similarly ,abnormalities in phenotype seen in the heterozygous individuals of some lines occur with incomplete penetrance. CONCLUSIONS: Recent advances in sequencing enhance the power of sensitized mutagenesis screens to identify the function of previously uncharacterized factors and to discover additional functions for previously characterized proteins. The observation of incomplete penetrance of phenotypes in these inbred mutant mice, at various stages of development, is of interest. Overall, the Momme collection of mouse mutants provides a valuable resource for researchers across many disciplines. Twit Text FOAVip An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse ????Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=24025402 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24025402 #FOAvip English Wikipedia <ref>{{Cite pmid|24025402 }}</ref> An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse #MMPMID24025402 Daxinger L ; Harten SK ; Oey H ; Epp T ; Isbel L ; Huang E ; Whitelaw N ; Apedaile A ; Sorolla A ; Yong J ; Bharti V ; Sutton J ; Ashe A ; Pang Z ; Wallace N ; Gerhardt DJ ; Blewitt ME ; Jeddeloh JA ; Whitelaw E Genome Biol 2013[]; 14 (9 ): R96 PMID24025402 show ga BACKGROUND: We have used a sensitized ENU mutagenesis screen to produce mouse lines that carry mutations in genes required for epigenetic regulation. We call these lines Modifiers of murine metastable epialleles (Mommes). RESULTS: We report a basic molecular and phenotypic characterization for twenty of the Momme mouse lines, and in each case we also identify the causative mutation. Three of the lines carry a mutation in a novel epigenetic modifier, Rearranged L-myc fusion (Rlf), and one gene, Rap-interacting factor 1 (Rif1), has not previously been reported to be involved in transcriptional regulation in mammals. Many of the other lines are novel alleles of known epigenetic regulators. For two genes, Rlf and Widely-interspaced zinc finger (Wiz), we describe the first mouse mutants. All of the Momme mutants show some degree of homozygous embryonic lethality, emphasizing the importance of epigenetic processes. The penetrance of lethality is incomplete in a number of cases. Similarly ,abnormalities in phenotype seen in the heterozygous individuals of some lines occur with incomplete penetrance. CONCLUSIONS: Recent advances in sequencing enhance the power of sensitized mutagenesis screens to identify the function of previously uncharacterized factors and to discover additional functions for previously characterized proteins. The observation of incomplete penetrance of phenotypes in these inbred mutant mice, at various stages of development, is of interest. Overall, the Momme collection of mouse mutants provides a valuable resource for researchers across many disciplines. |*Epigenesis, Genetic [MESH] |*Genes, Lethal [MESH] |*Mutagenesis [MESH] |Alleles [MESH] |Animals [MESH] |Ethylnitrosourea/*pharmacology [MESH] |Gene Expression Regulation [MESH] |Genome-Wide Association Study [MESH] |Genotype [MESH] |Guanine Nucleotide Exchange Factors [MESH] |Heterozygote [MESH] |Homozygote [MESH] |Kruppel-Like Transcription Factors/genetics [MESH] |Mice [MESH] |Mutagens/*pharmacology [MESH] |Mutation/*drug effects [MESH] |Nerve Tissue Proteins/genetics [MESH] |Phenotype [MESH] |Telomere-Binding Proteins/genetics [MESH]An ENU mutagenesis screen identifies novel and known genes involved in(epmc).pdf DeepDyve Pubget Overpricing