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10.1186/gb-2013-14-10-r108 http://scihub22266oqcxt.onion/10.1186/gb-2013-14-10-r108 C4053753!4053753!24098934     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genome+Biol 2013 ; 14 (10): R108 Nephropedia Template TP {{tp|p=24098934|t=2013. Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development |pdf=|usr=}}{{24098934}} gab.com Text Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development JO: Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=24098934 #FOAvip Background: One in eleven people is affected by chronic kidney disease, a condition characterized by kidney fibrosis and progressive loss of kidney function. Epidemiological studies indicate that adverse intrauterine and postnatal environments have a long-lasting role in chronic kidney disease development. Epigenetic information represents a plausible carrier for mediating this programming effect. Here we demonstrate that genome-wide cytosine methylation patterns of healthy and chronic kidney disease tubule samples obtained from patients show significant differences. Results: We identify differentially methylated regions and validate these in a large replication dataset. The differentially methylated regions are rarely observed on promoters, but mostly overlap with putative enhancer regions, and they are enriched in consensus binding sequences for important renal transcription factors. This indicates their importance in gene expression regulation. A core set of genes that are known to be related to kidney fibrosis, including genes encoding collagens, show cytosine methylation changes correlating with downstream transcript levels. Conclusions: Our report raises the possibility that epigenetic dysregulation plays a role in chronic kidney disease development via influencing core pro-fibrotic pathways and can aid the development of novel biomarkers and future therapeutics. Twit Text FOAVip Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development ????Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=24098934 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24098934 #FOAvip English Wikipedia <ref>{{Cite pmid|24098934}}</ref> Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development #MMPMID24098934 Ko YA; Mohtat D; Suzuki M; Park ASD; Izquierdo MC; Han SY; Kang HM; Si H; Hostetter T; Pullman JM; Fazzari M; Verma A; Zheng D; Greally JM; Susztak K Genome Biol 2013[]; 14 (10): R108 PMID24098934show ga Background: One in eleven people is affected by chronic kidney disease, a condition characterized by kidney fibrosis and progressive loss of kidney function. Epidemiological studies indicate that adverse intrauterine and postnatal environments have a long-lasting role in chronic kidney disease development. Epigenetic information represents a plausible carrier for mediating this programming effect. Here we demonstrate that genome-wide cytosine methylation patterns of healthy and chronic kidney disease tubule samples obtained from patients show significant differences. Results: We identify differentially methylated regions and validate these in a large replication dataset. The differentially methylated regions are rarely observed on promoters, but mostly overlap with putative enhancer regions, and they are enriched in consensus binding sequences for important renal transcription factors. This indicates their importance in gene expression regulation. A core set of genes that are known to be related to kidney fibrosis, including genes encoding collagens, show cytosine methylation changes correlating with downstream transcript levels. Conclusions: Our report raises the possibility that epigenetic dysregulation plays a role in chronic kidney disease development via influencing core pro-fibrotic pathways and can aid the development of novel biomarkers and future therapeutics. äCytosine methylation changes in enhancer regions of core pro-fibrotic (epmc).pdf DeepDyve Pubget Overpricing