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10.1007/s13539-013-0125-7 http://scihub22266oqcxt.onion/10.1007/s13539-013-0125-7 C4053568!4053568 !24272787     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24272787 &cmd=llinks): Failed to open stream: HTTP request failed! 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The anabolic catabolic transforming agent (ACTA) espindolol increases muscle mass and decreases fat mass in old rats |pdf=|usr=}}{{24272787 }} gab.com Text The anabolic catabolic transforming agent (ACTA) espindolol increases muscle mass and decreases fat mass in old rats JO: J Cachexia Sarcopenia Muscle http://www.kidney.de/pget.php?&tw=1&pmid=24272787 #FOAvip BACKGROUND: Sarcopenia, the age-related, progressive loss of skeletal muscle mass, strength, and function, is a considerable socioeconomic burden by increasing risks of falls, fractures, and frailty. Moreover, sarcopenic patients are often obese and therapeutic options are very limited. METHODS: Here, we assessed the efficacy of espindolol on muscle mass in 19-month-old male Wistar Han rats (weight, 555?±?18 g), including safety issues. Rats were randomized to treatment with 3 mg/kg/day espindolol (n?=?8) or placebo (n?=?14) for 31 days. RESULTS: Placebo-treated rats progressively lost body weight (-15.5?±?7.2 g), lean mass (-1.5?±?4.2 g), and fat mass (-15.6?±?2.7 g), while espindolol treatment increased body weight (+8.0?±?6.1 g, p?<?0.05), particularly lean mass (+43.4?±?3.5 g, p?<?0.001), and reduced fat mass further (-38.6?±?3.4 g, p?<?0.001). Anabolic/catabolic signaling was assessed in gastrocnemius muscle. Espindolol decreased proteasome and caspase-3 proteolytic activities by approximately 50 % (all p?<?0.05). Western blotting showed a reduced expression of key catabolic regulators, including NF?B, MuRF1, and LC-3 (all p?<?0.01). The 50- and 26-kDa forms of myostatin were downregulated fivefold and 20-fold, respectively (both p?<?0.001). Moreover, 4E-BP-1 was reduced fivefold (p?<?0.01), while phospho-PI3K was upregulated fivefold (p?<?0.001), although Akt expression and phosphorylation were lower compared to placebo (all p?<?0.05). No regulation of p38 and expression of ERK1/2 were observed, while phosphorylation of p38 was reduced (-54 %, p?<?0.001) and ERK1/2 was increased (115 and 83 %, respectively, both p?<?0.01). Espindolol did not affect cardiac function (echocardiography) or clinical plasma parameters. CONCLUSION: Espindolol reversed the effects of aging/sarcopenia, particularly loss of muscle mass and increased fat mass. Thus, espindolol is an attractive candidate drug for the treatment of sarcopenia patients. Twit Text FOAVip The anabolic catabolic transforming agent (ACTA) espindolol increases muscle mass and decreases fat mass in old rats ????J Cachexia Sarcopenia Muscle http://www.kidney.de/pget.php?&tw=1&pmid=24272787 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24272787 #FOAvip English Wikipedia <ref>{{Cite pmid|24272787 }}</ref> The anabolic catabolic transforming agent (ACTA) espindolol increases muscle mass and decreases fat mass in old rats #MMPMID24272787 Pötsch MS ; Tschirner A ; Palus S ; von Haehling S ; Doehner W ; Beadle J ; Coats AJ ; Anker SD ; Springer J J Cachexia Sarcopenia Muscle 2014[Jun]; 5 (2 ): 149-58 PMID24272787 show ga BACKGROUND: Sarcopenia, the age-related, progressive loss of skeletal muscle mass, strength, and function, is a considerable socioeconomic burden by increasing risks of falls, fractures, and frailty. Moreover, sarcopenic patients are often obese and therapeutic options are very limited. METHODS: Here, we assessed the efficacy of espindolol on muscle mass in 19-month-old male Wistar Han rats (weight, 555?±?18 g), including safety issues. Rats were randomized to treatment with 3 mg/kg/day espindolol (n?=?8) or placebo (n?=?14) for 31 days. RESULTS: Placebo-treated rats progressively lost body weight (-15.5?±?7.2 g), lean mass (-1.5?±?4.2 g), and fat mass (-15.6?±?2.7 g), while espindolol treatment increased body weight (+8.0?±?6.1 g, p? äThe anabolic catabolic transforming agent (ACTA) espindolol increases (epmc).pdf DeepDyve Pubget Overpricing