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10.1016/j.clim.2013.12.007 http://scihub22266oqcxt.onion/10.1016/j.clim.2013.12.007 C4053206!4053206!24440645     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Immunol 2014 ; 150 (2): 201-9 Nephropedia Template TP {{tp|p=24440645|t=2014. SLAP deficiency decreases dsDNA autoantibody production |pdf=|usr=}}{{24440645}} gab.com Text SLAP deficiency decreases dsDNA autoantibody production JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24440645 #FOAvip Src-like adaptor protein (SLAP) adapts c-Cbl, an E3 ubiquitin ligase, to activated components of the BCR signaling complex regulating BCR levels and signaling in developing B cells. Based on this function, we asked whether SLAP deficiency could decrease the threshold for tolerance and eliminate development of autoreactive B cells in two models of autoantibody production. First, we sensitized mice with a dsDNA mimetope that causes an anti-dsDNA response. Despite equivalent production of anti-peptide antibodies compared to BALB/c controls, SLAP?/? mice did not produce anti-dsDNA. Second, we used the 56R tolerance model. SLAP?/? 56R mice had decreased levels of dsDNA-reactive antibodies compared to 56R mice due to skewed light chain usage. Thus, SLAP is a critical regulator of B-cell development and function and its deficiency leads to decreased autoreactive B cells that are otherwise maintained by inefficient receptor editing or failed negative selection. Twit Text FOAVip SLAP deficiency decreases dsDNA autoantibody production ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24440645 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24440645 #FOAvip English Wikipedia <ref>{{Cite pmid|24440645}}</ref> SLAP deficiency decreases dsDNA autoantibody production #MMPMID24440645 Peterson LK; Pennington LF; Shaw LA; Brown M; Treacy EC; Friend SF; Hatlevik Ø; Rubtsova K; Rubtsov AV; Dragone LL Clin Immunol 2014[Feb]; 150 (2): 201-9 PMID24440645show ga Src-like adaptor protein (SLAP) adapts c-Cbl, an E3 ubiquitin ligase, to activated components of the BCR signaling complex regulating BCR levels and signaling in developing B cells. Based on this function, we asked whether SLAP deficiency could decrease the threshold for tolerance and eliminate development of autoreactive B cells in two models of autoantibody production. First, we sensitized mice with a dsDNA mimetope that causes an anti-dsDNA response. Despite equivalent production of anti-peptide antibodies compared to BALB/c controls, SLAP?/? mice did not produce anti-dsDNA. Second, we used the 56R tolerance model. SLAP?/? 56R mice had decreased levels of dsDNA-reactive antibodies compared to 56R mice due to skewed light chain usage. Thus, SLAP is a critical regulator of B-cell development and function and its deficiency leads to decreased autoreactive B cells that are otherwise maintained by inefficient receptor editing or failed negative selection. äSLAP deficiency decreases dsDNA autoantibody production (epmc).pdf DeepDyve Pubget Overpricing