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10.1155/2014/340216 http://scihub22266oqcxt.onion/10.1155/2014/340216 C4052551!4052551 !24949434     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24949434 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biomed+Res+Int 2014 ; 2014 (ä): 340216 Nephropedia Template TP {{tp|p=24949434 |t=2014. Gla-rich protein is a potential new vitamin K target in cancer: evidences for a direct GRP-mineral interaction |pdf=|usr=}}{{24949434 }} gab.com Text Gla-rich protein is a potential new vitamin K target in cancer: evidences for a direct GRP-mineral interaction JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=24949434 #FOAvip Gla-rich protein (GRP) was described in sturgeon as a new vitamin-K-dependent protein (VKDP) with a high density of Gla residues and associated with ectopic calcifications in humans. Although VKDPs function has been related with ?-carboxylation, the Gla status of GRP in humans is still unknown. Here, we investigated the expression of recently identified GRP spliced transcripts, the ?-carboxylation status, and its association with ectopic calcifications, in skin basal cell and breast carcinomas. GRP-F1 was identified as the predominant splice variant expressed in healthy and cancer tissues. Patterns of ?-carboxylated GRP (cGRP)/undercarboxylated GRP (ucGRP) accumulation in healthy and cancer tissues were determined by immunohistochemistry, using newly developed conformation-specific antibodies. Both GRP protein forms were found colocalized in healthy tissues, while ucGRP was the predominant form associated with tumor cells. Both cGRP and ucGRP found at sites of microcalcifications were shown to have in vitro calcium mineral-binding capacity. The decreased levels of cGRP and predominance of ucGRP in tumor cells suggest that GRP may represent a new target for the anticancer potential of vitamin K. Also, the direct interaction of cGRP and ucGRP with BCP crystals provides a possible mechanism explaining GRP association with pathological mineralization. Twit Text FOAVip Gla-rich protein is a potential new vitamin K target in cancer: evidences for a direct GRP-mineral interaction ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=24949434 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24949434 #FOAvip English Wikipedia <ref>{{Cite pmid|24949434 }}</ref> Gla-rich protein is a potential new vitamin K target in cancer: evidences for a direct GRP-mineral interaction #MMPMID24949434 Viegas CS ; Herfs M ; Rafael MS ; Enriquez JL ; Teixeira A ; Luís IM ; van 't Hoofd CM ; João A ; Maria VL ; Cavaco S ; Ferreira A ; Serra M ; Theuwissen E ; Vermeer C ; Simes DC Biomed Res Int 2014[]; 2014 (ä): 340216 PMID24949434 show ga Gla-rich protein (GRP) was described in sturgeon as a new vitamin-K-dependent protein (VKDP) with a high density of Gla residues and associated with ectopic calcifications in humans. Although VKDPs function has been related with ?-carboxylation, the Gla status of GRP in humans is still unknown. Here, we investigated the expression of recently identified GRP spliced transcripts, the ?-carboxylation status, and its association with ectopic calcifications, in skin basal cell and breast carcinomas. GRP-F1 was identified as the predominant splice variant expressed in healthy and cancer tissues. Patterns of ?-carboxylated GRP (cGRP)/undercarboxylated GRP (ucGRP) accumulation in healthy and cancer tissues were determined by immunohistochemistry, using newly developed conformation-specific antibodies. Both GRP protein forms were found colocalized in healthy tissues, while ucGRP was the predominant form associated with tumor cells. Both cGRP and ucGRP found at sites of microcalcifications were shown to have in vitro calcium mineral-binding capacity. The decreased levels of cGRP and predominance of ucGRP in tumor cells suggest that GRP may represent a new target for the anticancer potential of vitamin K. Also, the direct interaction of cGRP and ucGRP with BCP crystals provides a possible mechanism explaining GRP association with pathological mineralization. |*Calcinosis [MESH] |Breast Neoplasms/*metabolism/pathology [MESH] |Carcinoma, Basal Cell/*metabolism/pathology [MESH] |Female [MESH] |Humans [MESH] |Naphthoquinones [MESH] |Osteocalcin/metabolism [MESH] |Skin Neoplasms/*metabolism/pathology [MESH] |Vitamin K/metabolism [MESH]Gla-rich protein is a potential new vitamin K target in cancer: eviden(epmc).pdf DeepDyve Pubget Overpricing