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10.1155/2014/802841 http://scihub22266oqcxt.onion/10.1155/2014/802841 C4052161!4052161!24949470     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2014 ; 2014 (ä): ä Nephropedia Template TP {{tp|p=24949470|t=2014. Gremlin Activates the Smad Pathway Linked to Epithelial Mesenchymal Transdifferentiation in Cultured Tubular Epithelial Cells |pdf=|usr=}}{{24949470}} gab.com Text Gremlin Activates the Smad Pathway Linked to Epithelial Mesenchymal Transdifferentiation in Cultured Tubular Epithelial Cells JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=24949470 #FOAvip Gremlin is a developmental gene upregulated in human chronic kidney disease and in renal cells in response to transforming growth factor-? (TGF-?). Epithelial mesenchymal transition (EMT) is one process involved in renal fibrosis. In tubular epithelial cells we have recently described that Gremlin induces EMT and acts as a downstream TGF-? mediator. Our aim was to investigate whether Gremlin participates in EMT by the regulation of the Smad pathway. Stimulation of human tubular epithelial cells (HK2) with Gremlin caused an early activation of the Smad signaling pathway (Smad 2/3 phosphorylation, nuclear translocation, and Smad-dependent gene transcription). The blockade of TGF-?, by a neutralizing antibody against active TGF-?, did not modify Gremlin-induced early Smad activation. These data show that Gremlin directly, by a TGF-? independent process, activates the Smad pathway. In tubular epithelial cells long-term incubation with Gremlin increased TGF-? production and caused a sustained Smad activation and a phenotype conversion into myofibroblasts-like cells. Smad 7 overexpression, which blocks Smad 2/3 activation, diminished EMT changes observed in Gremlin-transfected tubuloepithelial cells. TGF-? neutralization also diminished Gremlin-induced EMT changes. In conclusion, we propose that Gremlin could participate in renal fibrosis by inducing EMT in tubular epithelial cells through activation of Smad pathway and induction of TGF-?. Twit Text FOAVip Gremlin Activates the Smad Pathway Linked to Epithelial Mesenchymal Transdifferentiation in Cultured Tubular Epithelial Cells ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=24949470 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24949470 #FOAvip English Wikipedia <ref>{{Cite pmid|24949470}}</ref> Gremlin Activates the Smad Pathway Linked to Epithelial Mesenchymal Transdifferentiation in Cultured Tubular Epithelial Cells #MMPMID24949470 Rodrigues-Diez R; Rodrigues-Diez RR; Lavoz C; Carvajal G; Droguett A; Garcia-Redondo AB; Rodriguez I; Ortiz A; Egido J; Mezzano S; Ruiz-Ortega M Biomed Res Int 2014[]; 2014 (ä): ä PMID24949470show ga Gremlin is a developmental gene upregulated in human chronic kidney disease and in renal cells in response to transforming growth factor-? (TGF-?). Epithelial mesenchymal transition (EMT) is one process involved in renal fibrosis. In tubular epithelial cells we have recently described that Gremlin induces EMT and acts as a downstream TGF-? mediator. Our aim was to investigate whether Gremlin participates in EMT by the regulation of the Smad pathway. Stimulation of human tubular epithelial cells (HK2) with Gremlin caused an early activation of the Smad signaling pathway (Smad 2/3 phosphorylation, nuclear translocation, and Smad-dependent gene transcription). The blockade of TGF-?, by a neutralizing antibody against active TGF-?, did not modify Gremlin-induced early Smad activation. These data show that Gremlin directly, by a TGF-? independent process, activates the Smad pathway. In tubular epithelial cells long-term incubation with Gremlin increased TGF-? production and caused a sustained Smad activation and a phenotype conversion into myofibroblasts-like cells. Smad 7 overexpression, which blocks Smad 2/3 activation, diminished EMT changes observed in Gremlin-transfected tubuloepithelial cells. TGF-? neutralization also diminished Gremlin-induced EMT changes. In conclusion, we propose that Gremlin could participate in renal fibrosis by inducing EMT in tubular epithelial cells through activation of Smad pathway and induction of TGF-?. äGremlin Activates the Smad Pathway Linked to Epithelial Mesenchymal Tr(epmc).pdf DeepDyve Pubget Overpricing