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2014 ; 9
(ä): 29-37
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Folate receptor alpha, mesothelin and megakaryocyte potentiating factor as
potential serum markers of chronic kidney disease
#MMPMID24932099
Somers EB
; O'Shannessy DJ
Biomark Insights
2014[]; 9
(ä): 29-37
PMID24932099
show ga
Renal disease is the eighth leading cause of death in the United States. Early
diagnosis is usually based on the detection of proteinuria or elevated serum
creatinine, a relatively poor biomarker that does not accurately predict renal
disease progression. As a result, more predictive biomarkers of renal function
are sought. We present preliminary data on three protein biomarkers, folate
receptor alpha (FRA), mesothelin (MSLN), and megakaryocyte potentiating factor
(MPF), currently being pursued for applications in oncology diagnostics, and
evaluate serum and urine levels in subjects with renal disease. Compared to
healthy subjects, a significant (P < 0.0001) increase in all three biomarkers in
both serum and urine of subjects with renal disease was demonstrated. Further,
serum levels of these three protein biomarkers increased with increasing stage of
disease suggesting their potential value in predicting progression in subjects
with renal disease and raising caution in interpretation of data in oncology
applications.