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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biomed+Rep 2014 ; 2 (4): 447-51 Nephropedia Template TP
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Betatrophin provides a new insight into diabetes treatment and lipid metabolism (Review) #MMPMID24944788
ZHU JZ; YU CH; LI YM
Biomed Rep 2014[Jul]; 2 (4): 447-51 PMID24944788show ga
Replenishing the insulin-producing ?-cell mass is considered to be a potential cure for diabetes. A recent study identified a secreted protein, known as betatrophin, which potently induces pancreatic ?-cell proliferation. Notably, a number of studies reportedly identified betatrophin, which is also known as lipasin, atypical angiopoietin-like 8 and refeeding-induced fat and liver protein, and considered to be a novel regulator in lipid metabolism according to the studies. The identification of betatrophin was considered to create novel opportunities for potential diabetes therapy. In the present study, the current knowledge of betatrophin is reviewed, with regards to its character and function in lipid homeostasis and pancreatic ?-cell proliferation.