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10.3892/br.2014.277 http://scihub22266oqcxt.onion/10.3892/br.2014.277 C4051486!4051486!24944793     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Rep 2014 ; 2 (4): 490-4 Nephropedia Template TP {{tp|p=24944793|t=2014. Effect of benazepril on the transdifferentiation of renal tubular epithelial cells from diabetic rats |pdf=|usr=}}{{24944793}} gab.com Text Effect of benazepril on the transdifferentiation of renal tubular epithelial cells from diabetic rats JO: Biomed Rep http://www.kidney.de/pget.php?&tw=1&pmid=24944793 #FOAvip The aim of this study was to investigate the effect of benazepril on the transdifferentiation of renal tubular epithelial cells from diabetic rats. Thirty male Sprague-Dawley rats were included in the present study. Eight of the 30 rats were randomly selected and served as the normal control group (N group), while the remaining 22 rats, injected with streptozotocin (STZ), comprised the diabetic rat model. Rats with diabetes were randomly divided into the diabetic (DM group) and benazepril (B group) groups. The total course was conducted over 12 weeks. Blood glucose, body weight, kidney/body weight, 24-h urinary protein, serum creatinine and blood urea nitrogen were measured at the start and end of the study. We observed the tubulointerstitial pathological changes, and applied immunohistochemistry and western blotting to detect the expression of ?-smooth muscle actin (?-SMA) in renal tissue. The levels of blood glucose, kidney/body weight, 24-h urinary protein, serum creatinine, blood urea nitrogen and tubulointerstitial damage index (TII) in the DM group were significantly higher than that in the N group (p<0.01). Except for blood glucose and kidney/body weight, the remaining indices were lower in the B group compared with those in the DM group (p<0.01). Immunohistochemical staining results revealed the expression of ?-SMA in renal tubular epithelial cells to be significantly higher in the DM and B groups compared with the control (N) group (p<0.01). Western blot analysis revealed that the expression of ?-SMA in diabetic renal tissue increased 3.27-fold compared with that of the N group, while the expression of ?-SMA in the B group decreased 45% compared with that in the DM group. In conclusion, benazepril significantly reduced the expression of ?-SMA in renal tubular epithelial cells obtained from diabetic rats, inhibited the transdifferentiation of renal tubular epithelial cells and played an important role in kidney protection. Twit Text FOAVip Effect of benazepril on the transdifferentiation of renal tubular epithelial cells from diabetic rats ????Biomed Rep http://www.kidney.de/pget.php?&tw=1&pmid=24944793 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24944793 #FOAvip English Wikipedia <ref>{{Cite pmid|24944793}}</ref> Effect of benazepril on the transdifferentiation of renal tubular epithelial cells from diabetic rats #MMPMID24944793 PENG T; WANG J; ZHEN J; HU Z; YANG X Biomed Rep 2014[Jul]; 2 (4): 490-4 PMID24944793show ga The aim of this study was to investigate the effect of benazepril on the transdifferentiation of renal tubular epithelial cells from diabetic rats. Thirty male Sprague-Dawley rats were included in the present study. Eight of the 30 rats were randomly selected and served as the normal control group (N group), while the remaining 22 rats, injected with streptozotocin (STZ), comprised the diabetic rat model. Rats with diabetes were randomly divided into the diabetic (DM group) and benazepril (B group) groups. The total course was conducted over 12 weeks. Blood glucose, body weight, kidney/body weight, 24-h urinary protein, serum creatinine and blood urea nitrogen were measured at the start and end of the study. We observed the tubulointerstitial pathological changes, and applied immunohistochemistry and western blotting to detect the expression of ?-smooth muscle actin (?-SMA) in renal tissue. The levels of blood glucose, kidney/body weight, 24-h urinary protein, serum creatinine, blood urea nitrogen and tubulointerstitial damage index (TII) in the DM group were significantly higher than that in the N group (p<0.01). Except for blood glucose and kidney/body weight, the remaining indices were lower in the B group compared with those in the DM group (p<0.01). Immunohistochemical staining results revealed the expression of ?-SMA in renal tubular epithelial cells to be significantly higher in the DM and B groups compared with the control (N) group (p<0.01). Western blot analysis revealed that the expression of ?-SMA in diabetic renal tissue increased 3.27-fold compared with that of the N group, while the expression of ?-SMA in the B group decreased 45% compared with that in the DM group. In conclusion, benazepril significantly reduced the expression of ?-SMA in renal tubular epithelial cells obtained from diabetic rats, inhibited the transdifferentiation of renal tubular epithelial cells and played an important role in kidney protection. äEffect of benazepril on the transdifferentiation of renal tubular epit(epmc).pdf DeepDyve Pubget Overpricing