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10.1097/CCM.0b013e31820ed8a6 http://scihub22266oqcxt.onion/10.1097/CCM.0b013e31820ed8a6 C4051346!4051346 !21358401     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21358401 &cmd=llinks): Failed to open stream: HTTP request failed! 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Sodium nitroprusside enhanced cardiopulmonary resuscitation improves survival with good neurological function in a porcine model of prolonged cardiac arrest |pdf=|usr=}}{{21358401 }} gab.com Text Sodium nitroprusside enhanced cardiopulmonary resuscitation improves survival with good neurological function in a porcine model of prolonged cardiac arrest JO: Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=21358401 #FOAvip OBJECTIVE: To assess the effectiveness of sodium nitroprusside (SNP)-"enhanced" cardiopulmonary resuscitation (SNPeCPR) on 24-hr survival rates compared to standard CPR in animals after cardiac arrest. SNPeCPR consists of large intravenous SNP bolus doses during CPR enhanced by active compression-decompression CPR, an inspiratory impedance threshold device (ITD), and abdominal binding (AB). The combination of active compression-decompression CPR+ITD+AB without SNP will be called "enhanced" or eCPR. DESIGN: Randomized, blinded, animal study. SETTING: Preclinical animal laboratory. SUBJECTS: Twenty-four female farm pigs (30 ± 1 kg). INTERVENTIONS: Isoflurane anesthetized and intubated pigs were randomized after 8 mins of untreated ventricular fibrillation to receive either standard CPR (n = 8), SNPeCPR (n = 8), or eCPR (n = 8) for 25 mins followed by defibrillation. MEASUREMENTS AND MAIN RESULTS: The primary end point was carotid blood flow during CPR and 24-hr survival with good neurologic function defined as an overall performance category score of ?2 (1 = normal, 5 = brain dead or dead). Secondary end points included hemodynamics and end-tidal CO2. SNPeCPR significantly improved carotid blood flow and 24-hr survival rates with good neurologic function compared to standard CPR or eCPR (six of eight vs. zero of eight vs. one of eight, p < .05). The improved survival rates were associated with higher coronary perfusion pressure and ETco2 during CPR. CONCLUSION: In pigs, SNPeCPR significantly improved hemodynamics, resuscitation rates, and 24-hr survival rates with good neurologic function after cardiac arrest when compared with standard CPR or eCPR alone. Twit Text FOAVip Sodium nitroprusside enhanced cardiopulmonary resuscitation improves survival with good neurological function in a porcine model of prolonged cardiac arrest ????Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=21358401 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21358401 #FOAvip English Wikipedia <ref>{{Cite pmid|21358401 }}</ref> Sodium nitroprusside enhanced cardiopulmonary resuscitation improves survival with good neurological function in a porcine model of prolonged cardiac arrest #MMPMID21358401 Yannopoulos D ; Matsuura T ; Schultz J ; Rudser K ; Halperin HR ; Lurie KG Crit Care Med 2011[Jun]; 39 (6 ): 1269-74 PMID21358401 show ga OBJECTIVE: To assess the effectiveness of sodium nitroprusside (SNP)-"enhanced" cardiopulmonary resuscitation (SNPeCPR) on 24-hr survival rates compared to standard CPR in animals after cardiac arrest. SNPeCPR consists of large intravenous SNP bolus doses during CPR enhanced by active compression-decompression CPR, an inspiratory impedance threshold device (ITD), and abdominal binding (AB). The combination of active compression-decompression CPR+ITD+AB without SNP will be called "enhanced" or eCPR. DESIGN: Randomized, blinded, animal study. SETTING: Preclinical animal laboratory. SUBJECTS: Twenty-four female farm pigs (30 ± 1 kg). INTERVENTIONS: Isoflurane anesthetized and intubated pigs were randomized after 8 mins of untreated ventricular fibrillation to receive either standard CPR (n = 8), SNPeCPR (n = 8), or eCPR (n = 8) for 25 mins followed by defibrillation. MEASUREMENTS AND MAIN RESULTS: The primary end point was carotid blood flow during CPR and 24-hr survival with good neurologic function defined as an overall performance category score of ?2 (1 = normal, 5 = brain dead or dead). Secondary end points included hemodynamics and end-tidal CO2. SNPeCPR significantly improved carotid blood flow and 24-hr survival rates with good neurologic function compared to standard CPR or eCPR (six of eight vs. zero of eight vs. one of eight, p < .05). The improved survival rates were associated with higher coronary perfusion pressure and ETco2 during CPR. CONCLUSION: In pigs, SNPeCPR significantly improved hemodynamics, resuscitation rates, and 24-hr survival rates with good neurologic function after cardiac arrest when compared with standard CPR or eCPR alone. |Animals [MESH] |Cardiopulmonary Resuscitation/*methods [MESH] |Carotid Arteries/physiology [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Heart Arrest/etiology/*therapy [MESH] |Nitroprusside/*therapeutic use [MESH] |Regional Blood Flow [MESH] |Swine [MESH]Sodium nitroprusside enhanced cardiopulmonary resuscitation improves s(epmc).pdf DeepDyve Pubget Overpricing