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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Gastroenterol
2014 ; 109
(6
): 887-94
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Prucalopride improves bowel function and colonic transit time in patients with
chronic constipation: an integrated analysis
#MMPMID24732867
Emmanuel A
; Cools M
; Vandeplassche L
; Kerstens R
Am J Gastroenterol
2014[Jun]; 109
(6
): 887-94
PMID24732867
show ga
OBJECTIVES: Constipation is often characterized by slow colonic transit, but the
relationship between colonic transit time (CTT) and symptoms is unclear. The aims
of this study were to investigate the effect of prucalopride, a
5-hydroxytryptamine receptor-4 agonist, on CTT and assess the relationship
between CTT and symptoms. METHODS: This was an integrated analysis of three
randomized, placebo-controlled, phase 2 dose-finding trials of prucalopride in
patients with chronic constipation (ClinicalTrials.gov identifiers: NCT00617513;
NCT00631813; and NCT00596596). Measurements of CTT were analyzed using
radio-opaque markers at the start and end (4 or 12 weeks) of treatment. At these
visits, patients assessed the presence and severity of their symptoms. RESULTS:
In total, 280 patients had CTT measurements before and at the end of treatment
and were included in the analysis. Their mean age was 43 years, 93% were women,
and mean duration of constipation was 19 years. After a once daily treatment with
prucalopride 2 mg (n=98) and 4 mg (n=70), CTT was reduced by 12.0 h (95%
confidence interval (CI): -18.9, -5.1) and 13.9 h (95% CI: -20.5, -7.4),
respectively; CTT increased by 0.5 h (95% CI: -4.5, 5.5) with placebo (n=112). At
the end of the trial, symptoms including bloating/flatulence/distension and
straining were rated as severe or very severe by a higher proportion of patients
with slow or very slow CTT (>48 h) than by those with normal CTT. CONCLUSIONS:
There was a clear relationship between increased CTT and increased symptom
severity in patients with chronic constipation. Treatment with prucalopride
accelerated CTT in these individuals.
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