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10.1007/s00011-014-0727-3

http://scihub22266oqcxt.onion/10.1007/s00011-014-0727-3
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C4050291!4050291!24623532
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suck abstract from ncbi

pmid24623532      Inflamm+Res 2014 ; 63 (7): 519-25
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  • Role of Interleukin-22 in liver diseases #MMPMID24623532
  • Pan Cx; Tang J; Wang Xy; Wu Fr; Ge Jf; Chen Fh
  • Inflamm Res 2014[]; 63 (7): 519-25 PMID24623532show ga
  • Introduction: Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-derived inducible factor, is a member of the IL-10-like cytokine family. IL-22 is highly expressed by Th17 cells and is tightly linked to chronic inflammation, including inflammatory bowel disease and local intestinal inflammation among others. Materials and methods: A PubMed and Web of Science databases search was performed for studies providing evidences on the role of IL-22 in liver diseases. Conclusion: IL-22 plays an important role in ameliorating liver injury in many rodent models by targeting hepatocytes that express high levels of IL-22 receptor 1 and IL-10 receptor 2. This review concisely summarizes the role of IL-22 in the development progression of liver disease of different etiologies. It is focused mainly on the IL-22 intracellular signaling and its influence on liver diseases.
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