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10.1002/cbic.201300762 http://scihub22266oqcxt.onion/10.1002/cbic.201300762 C4050061!4050061!24591193     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chembiochem 2014 ; 15 (6): 799-804 Nephropedia Template TP {{tp|p=24591193|t=2014. Grassypeptolides As Natural Inhibitors of Dipeptidyl Peptidase 8 and T-Cell Activation |pdf=|usr=}}{{24591193}} gab.com Text Grassypeptolides As Natural Inhibitors of Dipeptidyl Peptidase 8 and T-Cell Activation JO: Chembiochem http://www.kidney.de/pget.php?&tw=1&pmid=24591193 #FOAvip Natural products made by marine cyanobacteria are often highly modified peptides and depsipeptides that have the potential to act as inhibitors for proteases. In the interest of finding novel protease inhibition activity and selectivity grassypeptolide A (1) was screened against a panel of proteases and found to selectively inhibit DPP8 over DPP4. Grassypeptolides were also found to inhibit IL-2 production and proliferation in activated T-cells, consistent with a putative role of DPP8 in the immune system. These effects were also observed in Jurkat cells, and DPP activity in Jurkat cell cytosol was shown to be inhibited by grassypeptolides. In silico docking suggests two possible binding modes of grassypeptolides ? both at the active site of DPP8 and at one of the entrances to the internal cavity. Collectively these results suggest that grassypeptolides may be useful tool compounds in the study of DPP8 function. Twit Text FOAVip Grassypeptolides As Natural Inhibitors of Dipeptidyl Peptidase 8 and T-Cell Activation ????Chembiochem http://www.kidney.de/pget.php?&tw=1&pmid=24591193 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24591193 #FOAvip English Wikipedia <ref>{{Cite pmid|24591193}}</ref> Grassypeptolides As Natural Inhibitors of Dipeptidyl Peptidase 8 and T-Cell Activation #MMPMID24591193 Kwan JC; Liu Y; Ratnayake R; Hatano R; Kuribara A; Morimoto C; Ohnuma K; Paul VJ; Ye T; Luesch H Chembiochem 2014[Apr]; 15 (6): 799-804 PMID24591193show ga Natural products made by marine cyanobacteria are often highly modified peptides and depsipeptides that have the potential to act as inhibitors for proteases. In the interest of finding novel protease inhibition activity and selectivity grassypeptolide A (1) was screened against a panel of proteases and found to selectively inhibit DPP8 over DPP4. Grassypeptolides were also found to inhibit IL-2 production and proliferation in activated T-cells, consistent with a putative role of DPP8 in the immune system. These effects were also observed in Jurkat cells, and DPP activity in Jurkat cell cytosol was shown to be inhibited by grassypeptolides. In silico docking suggests two possible binding modes of grassypeptolides ? both at the active site of DPP8 and at one of the entrances to the internal cavity. Collectively these results suggest that grassypeptolides may be useful tool compounds in the study of DPP8 function. äGrassypeptolides As Natural Inhibitors of Dipeptidyl Peptidase 8 and T(epmc).pdf DeepDyve Pubget Overpricing