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10.4161/cbt.28411 http://scihub22266oqcxt.onion/10.4161/cbt.28411 C4049780!4049780!24618703     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24618703&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 500 Internal Server Error in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cancer+Biol+Ther 2014 ; 15 (6): 655-64 Nephropedia Template TP {{tp|p=24618703|t=2014. The emerging roles of ARID1A in tumor suppression |pdf=|usr=}}{{24618703}} gab.com Text The emerging roles of ARID1A in tumor suppression JO: Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24618703 #FOAvip ARID1A has emerged as a tumor suppressor gene, which is mutated in a broad spectrum of cancers, especially in those arising from ectopic or eutopic endometrium. As a subunit of SWI/SNF chromatin remodeler, ARID1A facilitates target-specific binding of SWI/SNF complexes to chromatin, thereby altering the accessibility of chromatin to a variety of nuclear factors. In human cancer, ARID1A possesses not only features of a gatekeeper, regulating cell cycle progression, but also features of a caretaker, preventing genomic instability. An increasing body of evidence suggests crosstalk between ARID1A and PI3K/Akt pathways, and between ARID1A and p53. In this review, we discuss the spectrum of ARID1A alterations in cancers, tumor suppression mechanisms of ARID1A, oncogenic pathways cooperating with ARID1A, and clinical implications of ARID1A mutation. Twit Text FOAVip The emerging roles of ARID1A in tumor suppression ????Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24618703 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24618703 #FOAvip English Wikipedia <ref>{{Cite pmid|24618703}}</ref> The emerging roles of ARID1A in tumor suppression #MMPMID24618703 Wu RC; Wang TL; Shih Ie-M Cancer Biol Ther 2014[Jun]; 15 (6): 655-64 PMID24618703show ga ARID1A has emerged as a tumor suppressor gene, which is mutated in a broad spectrum of cancers, especially in those arising from ectopic or eutopic endometrium. As a subunit of SWI/SNF chromatin remodeler, ARID1A facilitates target-specific binding of SWI/SNF complexes to chromatin, thereby altering the accessibility of chromatin to a variety of nuclear factors. In human cancer, ARID1A possesses not only features of a gatekeeper, regulating cell cycle progression, but also features of a caretaker, preventing genomic instability. An increasing body of evidence suggests crosstalk between ARID1A and PI3K/Akt pathways, and between ARID1A and p53. In this review, we discuss the spectrum of ARID1A alterations in cancers, tumor suppression mechanisms of ARID1A, oncogenic pathways cooperating with ARID1A, and clinical implications of ARID1A mutation. äThe emerging roles of ARID1A in tumor suppression (epmc).pdf DeepDyve Pubget Overpricing