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2014 ; 14
(ä): 61
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Network-meta analysis made easy: detection of inconsistency using factorial
analysis-of-variance models
#MMPMID24885590
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BMC Med Res Methodol
2014[May]; 14
(ä): 61
PMID24885590
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BACKGROUND: Network meta-analysis can be used to combine results from several
randomized trials involving more than two treatments. Potential inconsistency
among different types of trial (designs) differing in the set of treatments
tested is a major challenge, and application of procedures for detecting and
locating inconsistency in trial networks is a key step in the conduct of such
analyses. METHODS: Network meta-analysis can be very conveniently performed using
factorial analysis-of-variance methods. Inconsistency can be scrutinized by
inspecting the design × treatment interaction. This approach is in many ways
simpler to implement than the more common approach of using
treatment-versus-control contrasts. RESULTS: We show that standard regression
diagnostics available in common linear mixed model packages can be used to detect
and locate inconsistency in trial networks. Moreover, a suitable definition of
factors and effects allows devising significance tests for inconsistency.
CONCLUSION: Factorial analysis of variance provides a convenient framework for
conducting network meta-analysis, including diagnostic checks for inconsistency.
|Analysis of Variance
[MESH]
|Biomedical Research/*methods/*statistics & numerical data
[MESH]