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10.1016/j.celrep.2014.02.033 http://scihub22266oqcxt.onion/10.1016/j.celrep.2014.02.033 C4049224!4049224!24656820     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2014 ; 7 (1): 127-37 Nephropedia Template TP {{tp|p=24656820|t=2014. The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment |pdf=|usr=}}{{24656820}} gab.com Text The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=24656820 #FOAvip Nephrons, the functional units of the kidney, develop from progenitor cells (cap mesenchyme, CM) surrounding the epithelial ureteric bud (UB) tips. Reciprocal signaling between UB and CM induces nephrogenesis and UB branching. While low nephron number is implicated in hypertension and renal disease, the mechanisms determining nephron number are obscure. To test the importance of nephron progenitor cell number, we genetically ablated 40% of these cells, asking if this would limit kidney size and nephron number, or if compensatory mechanisms would allow the developing organ to recover. The reduction in CM cell number decreased the rate of branching, in turn allowing the number of CM cells per UB tip to normalize, revealing a self-correction mechanism. However, the retarded UB branching impaired kidney growth, leaving a permanent nephron deficit. Thus, the number of fetal nephron progenitor cells is an important determinant of nephron endowment, largely via its effect on UB branching. Twit Text FOAVip The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=24656820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24656820 #FOAvip English Wikipedia <ref>{{Cite pmid|24656820}}</ref> The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment #MMPMID24656820 Cebrian C; Asai N; D?Agati V; Costantini F Cell Rep 2014[Apr]; 7 (1): 127-37 PMID24656820show ga Nephrons, the functional units of the kidney, develop from progenitor cells (cap mesenchyme, CM) surrounding the epithelial ureteric bud (UB) tips. Reciprocal signaling between UB and CM induces nephrogenesis and UB branching. While low nephron number is implicated in hypertension and renal disease, the mechanisms determining nephron number are obscure. To test the importance of nephron progenitor cell number, we genetically ablated 40% of these cells, asking if this would limit kidney size and nephron number, or if compensatory mechanisms would allow the developing organ to recover. The reduction in CM cell number decreased the rate of branching, in turn allowing the number of CM cells per UB tip to normalize, revealing a self-correction mechanism. However, the retarded UB branching impaired kidney growth, leaving a permanent nephron deficit. Thus, the number of fetal nephron progenitor cells is an important determinant of nephron endowment, largely via its effect on UB branching. äThe number of fetal nephron progenitor cells limits ureteric branching(epmc).pdf DeepDyve Pubget Overpricing