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10.1007/978-1-4614-0254-1_13 http://scihub22266oqcxt.onion/10.1007/978-1-4614-0254-1_13 C4049144!4049144 !21901626     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\21901626 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Exp+Med+Biol 2011 ; 720 (ä): 163-70 Nephropedia Template TP {{tp|p=21901626 |t=2011. Mechanism of radiation carcinogenesis: role of the TGFBI gene and the inflammatory signaling cascade |pdf=|usr=}}{{21901626 }} gab.com Text Mechanism of radiation carcinogenesis: role of the TGFBI gene and the inflammatory signaling cascade JO: Adv Exp Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=21901626 #FOAvip Using an immortalized human bronchial epithelial cell line, we showed previously that the transforming growth factor beta-induced (TGFBI) gene was consistently downregulated by six- to sevenfold among radiation-induced tumorigenic human cells when compared with controls. Transfection of TGFBI gene into tumor cells resulted in a significant reduction in tumor growth as well as in vitro anchorage independent growth. The observations that TGFBI knock-out animals showed increased spontaneous tumor incidence and chemically induced tumors highlight the suppressive nature of the gene. There is evidence that extranuclear/extracellular targets are important in low-dose radiation response and that the cyclo-oxygenase-2 signaling pathway mediates the process. The involvement of NF?B-dependent cytokines and the resultant inflammatory response works in concert with in modulating radiation-induced bronchial carcinogenesis. Twit Text FOAVip Mechanism of radiation carcinogenesis: role of the TGFBI gene and the inflammatory signaling cascade ????Adv Exp Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=21901626 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21901626 #FOAvip English Wikipedia <ref>{{Cite pmid|21901626 }}</ref> Mechanism of radiation carcinogenesis: role of the TGFBI gene and the inflammatory signaling cascade #MMPMID21901626 Hei TK ; Zhao Y ; Zhou H ; Ivanov V Adv Exp Med Biol 2011[]; 720 (ä): 163-70 PMID21901626 show ga Using an immortalized human bronchial epithelial cell line, we showed previously that the transforming growth factor beta-induced (TGFBI) gene was consistently downregulated by six- to sevenfold among radiation-induced tumorigenic human cells when compared with controls. Transfection of TGFBI gene into tumor cells resulted in a significant reduction in tumor growth as well as in vitro anchorage independent growth. The observations that TGFBI knock-out animals showed increased spontaneous tumor incidence and chemically induced tumors highlight the suppressive nature of the gene. There is evidence that extranuclear/extracellular targets are important in low-dose radiation response and that the cyclo-oxygenase-2 signaling pathway mediates the process. The involvement of NF?B-dependent cytokines and the resultant inflammatory response works in concert with in modulating radiation-induced bronchial carcinogenesis. |Animals [MESH] |Chromosome Aberrations [MESH] |Cyclooxygenase 2 Inhibitors/pharmacology [MESH] |Extracellular Matrix Proteins/genetics/*physiology [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Inflammation/*complications [MESH] |MAP Kinase Signaling System [MESH] |NF-kappa B/physiology [MESH] |Neoplasms, Radiation-Induced/*etiology [MESH] |Signal Transduction/*physiology [MESH]Mechanism of radiation carcinogenesis: role of the TGFBI gene and the (epmc).pdf DeepDyve Pubget Overpricing