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10.1002/eji.201344062 http://scihub22266oqcxt.onion/10.1002/eji.201344062 C4048633!4048633!24700192     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2014 ; 44 (6): 1728-36 Nephropedia Template TP {{tp|p=24700192|t=2014. TGF-?-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance |pdf=|usr=}}{{24700192}} gab.com Text TGF- -producing regulatory B cells induce regulatory T cells and promote transplantation tolerance JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24700192 #FOAvip Regulatory B cells (Bregs) have been shown to play a critical role in immune homeostasis and in autoimmunity models. We have recently demonstrated that combined anti-TIM-1 and anti-CD45RB antibody treatment results in tolerance to full MHC-mismatched islet allografts in mice by generating Bregs that are necessary for tolerance. Bregs are antigen-specific and are capable of transferring tolerance to untreated, transplanted animals. Here we demonstrate that adoptively transferred Bregs require the presence of Tregs to establish tolerance, and that adoptive transfer of Bregs increases the number of Tregs. Interaction with Bregs in vivo induces significantly more Foxp3 expression in CD4+CD25? T cells than with naive B cells. We also show that Bregs express the TGF-? associated latency-associated peptide (LAP) and that Breg-mediated graft prolongation post-adoptive transfer is abrogated by neutralization of TGF-? activity. Regulatory B cells, like regulatory T cells, demonstrate preferential expression of both CCR6 and CXCR3. Collectively, these findings suggest that in this model of antibody-induced transplantation tolerance, Bregs promote graft survival by promoting Treg development, possibly via TGF-? production. Twit Text FOAVip TGF- -producing regulatory B cells induce regulatory T cells and promote transplantation tolerance ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24700192 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24700192 #FOAvip English Wikipedia <ref>{{Cite pmid|24700192}}</ref> TGF-?-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance #MMPMID24700192 Lee KM; Stott RT; Zhao G; SooHoo J; Xiong W; Lian MM; Fitzgerald L; Shi S; Akrawi E; Lei J; Deng S; Yeh H; Markmann JF; Kim JI Eur J Immunol 2014[Jun]; 44 (6): 1728-36 PMID24700192show ga Regulatory B cells (Bregs) have been shown to play a critical role in immune homeostasis and in autoimmunity models. We have recently demonstrated that combined anti-TIM-1 and anti-CD45RB antibody treatment results in tolerance to full MHC-mismatched islet allografts in mice by generating Bregs that are necessary for tolerance. Bregs are antigen-specific and are capable of transferring tolerance to untreated, transplanted animals. Here we demonstrate that adoptively transferred Bregs require the presence of Tregs to establish tolerance, and that adoptive transfer of Bregs increases the number of Tregs. Interaction with Bregs in vivo induces significantly more Foxp3 expression in CD4+CD25? T cells than with naive B cells. We also show that Bregs express the TGF-? associated latency-associated peptide (LAP) and that Breg-mediated graft prolongation post-adoptive transfer is abrogated by neutralization of TGF-? activity. Regulatory B cells, like regulatory T cells, demonstrate preferential expression of both CCR6 and CXCR3. Collectively, these findings suggest that in this model of antibody-induced transplantation tolerance, Bregs promote graft survival by promoting Treg development, possibly via TGF-? production. äTGF-?-producing regulatory B cells induce regulatory T cells and promo(epmc).pdf DeepDyve Pubget Overpricing