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10.1002/eji.201344062

http://scihub22266oqcxt.onion/10.1002/eji.201344062
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C4048633!4048633 !24700192
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suck abstract from ncbi


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pmid24700192
      Eur+J+Immunol 2014 ; 44 (6 ): 1728-36
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  • TGF-?-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance #MMPMID24700192
  • Lee KM ; Stott RT ; Zhao G ; SooHoo J ; Xiong W ; Lian MM ; Fitzgerald L ; Shi S ; Akrawi E ; Lei J ; Deng S ; Yeh H ; Markmann JF ; Kim JI
  • Eur J Immunol 2014[Jun]; 44 (6 ): 1728-36 PMID24700192 show ga
  • Regulatory B (Breg) cells have been shown to play a critical role in immune homeostasis and in autoimmunity models. We have recently demonstrated that combined anti-T cell immunoglobulin domain and mucin domain-1 and anti-CD45RB antibody treatment results in tolerance to full MHC-mismatched islet allografts in mice by generating Breg cells that are necessary for tolerance. Breg cells are antigen-specific and are capable of transferring tolerance to untreated, transplanted animals. Here, we demonstrate that adoptively transferred Breg cells require the presence of regulatory T (Treg) cells to establish tolerance, and that adoptive transfer of Breg cells increases the number of Treg cells. Interaction with Breg cells in vivo induces significantly more Foxp3 expression in CD4(+) CD25(-) T cells than with naive B cells. We also show that Breg cells express the TGF-? associated latency-associated peptide and that Breg-cell mediated graft prolongation post-adoptive transfer is abrogated by neutralization of TGF-? activity. Breg cells, like Treg cells, demonstrate preferential expression of both C-C chemokine receptor 6 and CXCR3. Collectively, these findings suggest that in this model of antibody-induced transplantation tolerance, Breg cells promote graft survival by promoting Treg-cell development, possibly via TGF-? production.
  • |*Transplantation Tolerance [MESH]
  • |Adoptive Transfer [MESH]
  • |Allografts [MESH]
  • |Animals [MESH]
  • |B-Lymphocyte Subsets/*immunology/pathology [MESH]
  • |Forkhead Transcription Factors/genetics/immunology [MESH]
  • |Gene Expression Regulation/genetics/immunology [MESH]
  • |Graft Survival/genetics/*immunology [MESH]
  • |Islets of Langerhans Transplantation/*immunology [MESH]
  • |Mice [MESH]
  • |Mice, Inbred BALB C [MESH]
  • |Mice, Knockout [MESH]
  • |Receptors, CCR6/genetics/immunology [MESH]
  • |Receptors, CXCR3/genetics/immunology [MESH]
  • |T-Lymphocytes, Regulatory/*immunology/pathology [MESH]


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