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10.1016/j.cell.2014.05.004 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.05.004 C4048464!4048464 !24856970     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24856970 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2014 ; 157 (6 ): 1445-1459 Nephropedia Template TP {{tp|p=24856970 |t=2014. Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation |pdf=|usr=}}{{24856970 }} gab.com Text Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=24856970 #FOAvip Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chromatin domains remain poorly understood. Recruitment of PRC1 to target sites has been proposed to occur through a hierarchical process, dependent on prior nucleation of PRC2 and placement of H3K27me3. Here, using a de novo targeting assay in mouse embryonic stem cells we unexpectedly discover that PRC1-dependent H2AK119ub1 leads to recruitment of PRC2 and H3K27me3 to effectively initiate a polycomb domain. This activity is restricted to variant PRC1 complexes, and genetic ablation experiments reveal that targeting of the variant PCGF1/PRC1 complex by KDM2B to CpG islands is required for normal polycomb domain formation and mouse development. These observations provide a surprising PRC1-dependent logic for PRC2 occupancy at target sites in vivo. Twit Text FOAVip Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=24856970 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24856970 #FOAvip English Wikipedia <ref>{{Cite pmid|24856970 }}</ref> Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation #MMPMID24856970 Blackledge NP ; Farcas AM ; Kondo T ; King HW ; McGouran JF ; Hanssen LLP ; Ito S ; Cooper S ; Kondo K ; Koseki Y ; Ishikura T ; Long HK ; Sheahan TW ; Brockdorff N ; Kessler BM ; Koseki H ; Klose RJ Cell 2014[Jun]; 157 (6 ): 1445-1459 PMID24856970 show ga Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chromatin domains remain poorly understood. Recruitment of PRC1 to target sites has been proposed to occur through a hierarchical process, dependent on prior nucleation of PRC2 and placement of H3K27me3. Here, using a de novo targeting assay in mouse embryonic stem cells we unexpectedly discover that PRC1-dependent H2AK119ub1 leads to recruitment of PRC2 and H3K27me3 to effectively initiate a polycomb domain. This activity is restricted to variant PRC1 complexes, and genetic ablation experiments reveal that targeting of the variant PCGF1/PRC1 complex by KDM2B to CpG islands is required for normal polycomb domain formation and mouse development. These observations provide a surprising PRC1-dependent logic for PRC2 occupancy at target sites in vivo. |Animals [MESH] |Bone Development [MESH] |CpG Islands [MESH] |Embryonic Stem Cells/*metabolism [MESH] |F-Box Proteins/chemistry/genetics/*metabolism [MESH] |Genes, Lethal [MESH] |Genome-Wide Association Study [MESH] |Histones/*metabolism [MESH] |Jumonji Domain-Containing Histone Demethylases/chemistry/genetics/*metabolism [MESH] |Mice [MESH] |Polycomb Repressive Complex 1/*metabolism [MESH] |Polycomb Repressive Complex 2/*metabolism [MESH]Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitm(epmc).pdf DeepDyve Pubget Overpricing