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2014 ; 16
(6
): 522-7
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Morbidity of total pancreatectomy with islet cell auto-transplantation compared
to total pancreatectomy alone
#MMPMID23992021
Bhayani NH
; Enomoto LM
; Miller JL
; Ortenzi G
; Kaifi JT
; Kimchi ET
; Staveley-O'Carroll KF
; Gusani NJ
HPB (Oxford)
2014[Jun]; 16
(6
): 522-7
PMID23992021
show ga
BACKGROUND: In pancreatitis, total pancreatectomy (TP) is an effective treatment
for refractory pain. Islet cell auto-transplantation (IAT) may mitigate resulting
endocrinopathy. Short-term morbidity data for TP + IAT and comparisons with TP
are limited. METHODS: This study, using 2005-2011 National Surgical Quality
Improvement Program data, examined patients with pancreatitis or benign
neoplasms. Morbidity after TP alone was compared with that after TP + IAT.
RESULTS: In 126 patients (40%) undergoing TP and 191 (60%) patients undergoing TP
+ IAT, the most common diagnosis was chronic pancreatitis. Benign neoplasms were
present in 46 (14%) patients, six of whom underwent TP + IAT. Patients in the TP
+ IAT group were younger and had fewer comorbidities than those in the TP group.
Despite this, major morbidity was more frequent after TP + IAT than after TP [n =
79 (41%) versus n = 36 (29%); P = 0.020]. Transfusions were more common after TP
+ IAT [n = 39 (20%) versus n = 9 (7%); P = 0.001], as was longer hospitalization
(13 days versus 9 days; P < 0.0001). There was no difference in mortality.
CONCLUSIONS: This study is the only comparative, multicentre study of TP and TP +
IAT. The TP + IAT group experienced higher rates of major morbidity and
transfusion, and longer hospitalizations. Better data on the longterm benefits of
TP + IAT are needed. In the interim, this study should inform physicians and
patients regarding the perioperative risks of TP + IAT.
|Adolescent
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Blood Transfusion
[MESH]
|Comorbidity
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Islets of Langerhans Transplantation/*adverse effects/methods/mortality
[MESH]
free
free
free
