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10.1016/j.cub.2014.04.008 http://scihub22266oqcxt.onion/10.1016/j.cub.2014.04.008 C4047983!4047983!24835455     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Biol 2014 ; 24 (11): 1227-33 Nephropedia Template TP {{tp|p=24835455|t=2014. GM130 is required for compartmental organization of dendritic Golgi outposts |pdf=|usr=}}{{24835455}} gab.com Text GM130 is required for compartmental organization of dendritic Golgi outposts JO: Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=24835455 #FOAvip Golgi complexes (Golgi) play important roles in the development and function of neurons [1?3]. Not only are Golgi present in the neuronal soma (somal Golgi) but they also exist in the dendrites as Golgi outposts [4?7]. Previous studies have shown that Golgi outposts serve as local microtubule organizing centers [8] and secretory stations in dendrites [6, 9]. It is unknown whether the structure and function of Golgi outposts differ from those of somal Golgi. Here we show in Drosophila that, unlike somal Golgi, the biochemically distinct cis, medial, and trans compartments of Golgi are often disconnected in dendrites in vivo. The Golgi structural protein GM130 is responsible for connecting distinct Golgi compartments in soma and dendritic branch points, and specific distribution of GM130 determines the compartmental organization of dendritic Golgi in dendritic shafts. We further show that compartmental organization regulates the role of Golgi in acentrosomal microtubule growth in dendrites and in dendritic branching. Our study provides insights into the structure and function of dendritic Golgi outposts as well as the regulation of compartmental organization of Golgi in general. Twit Text FOAVip GM130 is required for compartmental organization of dendritic Golgi outposts ????Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=24835455 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24835455 #FOAvip English Wikipedia <ref>{{Cite pmid|24835455}}</ref> GM130 is required for compartmental organization of dendritic Golgi outposts #MMPMID24835455 Zhou W; Chang J; Wang X; Savelieff MG; Zhao Y; Ke S; Ye B Curr Biol 2014[Jun]; 24 (11): 1227-33 PMID24835455show ga Golgi complexes (Golgi) play important roles in the development and function of neurons [1?3]. Not only are Golgi present in the neuronal soma (somal Golgi) but they also exist in the dendrites as Golgi outposts [4?7]. Previous studies have shown that Golgi outposts serve as local microtubule organizing centers [8] and secretory stations in dendrites [6, 9]. It is unknown whether the structure and function of Golgi outposts differ from those of somal Golgi. Here we show in Drosophila that, unlike somal Golgi, the biochemically distinct cis, medial, and trans compartments of Golgi are often disconnected in dendrites in vivo. The Golgi structural protein GM130 is responsible for connecting distinct Golgi compartments in soma and dendritic branch points, and specific distribution of GM130 determines the compartmental organization of dendritic Golgi in dendritic shafts. We further show that compartmental organization regulates the role of Golgi in acentrosomal microtubule growth in dendrites and in dendritic branching. Our study provides insights into the structure and function of dendritic Golgi outposts as well as the regulation of compartmental organization of Golgi in general. äGM130 is required for compartmental organization of dendritic Golgi ou(epmc).pdf DeepDyve Pubget Overpricing